We included 1667 participants from a population sample with 3 T MRI time-of-flight angiography (40-84 years, 46.5% men). Saccular IAs were defined as protrusions in the intracranial arteries ≥2 mm, while variants of the CoW were classified according to whether segments were missing or hypoplastic (< 1 mm). We used logistic regression, adjusting for age and IA risk factors, to assess whether participants with incomplete CoW variants had a greater prevalence of IA and whether participants with specific incomplete variants had a greater prevalence of IA.
Participants with an incomplete CoW had an increased prevalence of IA (OR, 2.3 [95% CI 1.05-5.04]). This was mainly driven by the variant missing all three communicating arteries (OR, 4.2 [95% CI 1.7-1 0.3]) and the variant missing the P1 segment of the posterior cerebral artery (OR, 3.6 [95% CI 1.2-10.1]). The combined prevalence of the two variants was 15.4% but accounted for 28% of the IAs.
The findings suggest that an incomplete CoW is associated with an increased risk of IA for adults in the general population.
方法:我们纳入了来自3TMRI飞行时间血管造影的人群样本的1667名参与者(40-84年,46.5%的男性)。囊状IAs被定义为颅内动脉中≥2mm的突起,而CoW的变体根据节段缺失或发育不良(<1mm)进行分类。我们使用逻辑回归,调整年龄和IA危险因素,评估CoW变异不完全的参与者是否有更高的IA患病率,以及特定不完全变异的参与者是否有更高的IA患病率.
结果:CoW不完整的参与者IA患病率增加(OR,2.3[95%CI1.05-5.04])。这主要是由缺少所有三个交通动脉的变体(OR,4.2[95%CI1.7-10.3])和缺少大脑后动脉P1段的变体(OR,3.6[95%CI1.2-10.1])。两种变体的合并患病率为15.4%,但占IAs的28%。
结论:研究结果表明,在普通人群中,不完全CoW与成年人IA风险增加相关。