PDF(Pubmed)
Abstract：
A pediatric patient suffered from renal and hepatic abscesses (through hepatorenal space) and recovered by antibiotics and other therapies. By clinical analysis, the multi-organ abscesses might be caused by bloodstream-disseminated infection. In order to identify the pathogen, we collected kidney biopsy tissue, swabs, and plasma samples, and used metagenomics next-generation sequencing (mNGS) and some traditional methods. The results revealed that polymicrobial especially anaerobic bacteremia (Bacteroides fragilis, et al.) contributed to the abscess formation. What is more, systematic human adenovirus C (HAdV-C) infection was shown, and the virus was isolated. The titer of HAdV-2 neutralizing antibodies was 1/4 in the plasma after symptoms onset. Although the exact mechanism of HAdV-2 infection in multiple abscess formation has not been clarified, the case of multi-organ abscesses in the context of polymicrobial especially anaerobic bacteremia and HAdV infection in healthy children is infrequent.
摘要：
一名儿科患者患有肾和肝脓肿（通过肝肾间隙），并通过抗生素和其他疗法康复。通过临床分析,多器官脓肿可能由血流播散性感染引起。为了鉴定病原体，我们收集了肾活检组织,拭子,和血浆样本，并使用宏基因组学下一代测序（mNGS）和一些传统方法。结果表明，微生物特别是厌氧菌血症（脆弱拟杆菌，etal.)促成了脓肿的形成。更重要的是，显示系统性人腺病毒C（HAdV-C）感染，病毒被分离。症状发作后血浆中HAdV-2中和抗体的滴度为1/4。虽然HAdV-2感染在多发性脓肿形成中的确切机制尚未阐明，在健康儿童中，在多微生物特别是厌氧性菌血症和HAdV感染的背景下，多器官脓肿的病例很少见。
