Abstract：
Sutures are considered as surgical materials that form excellent surfaces to integrate the postoperative parts of the body. These materials present suitable platforms for potential bacterial penetrations. Therefore, coating these biomedical materials with biocompatible compounds is seen as a potential approach to improve their properties while avoiding adverse effects. The aim of this study was to evaluate Arthrospira platensis, Haematacoccus pluvialis, Chlorella minutissima, Botyrococcus braunii, and Nostoc muscorum as potential surgical suture coating materials. Their crude extracts were absorbed into two different sutures as poly glycolic (90%)-co-lactic acid (10%) (PGLA) and poly dioxanone (PDO); then, their cytotoxic effects and antibacterial activities were examined. Both N. muscorum-coated sutures (PGLA and PDO) and A. platensis-coated (PGLA and PDO) sutures did not induce any toxic effect on L929 mouse fibroblast cells (>70% cell viability). The highest antibacterial activity against Staphylococcus aureus was achieved with N. muscorum-coated PGLA and A. platensis-coated PGLA at 11.18 ± 0.54 mm and 9.52 ± 1.15 mm, respectively. These sutures were examined by mechanical analysis, and found suitable according to ISO 10993-5. In comparison with the commercial antibacterial agent (chlorohexidine), the results proved that N. muscorum extract can be considered as the most promising suture coating material for the human applications.
摘要：
缝合线被认为是形成优良表面以整合身体的术后部分的手术材料。这些材料为潜在的细菌渗透提供了合适的平台。因此,用生物相容性化合物涂覆这些生物医学材料被视为改善其性能同时避免不利影响的潜在方法。本研究的目的是评估钝顶螺旋体，雨生血球菌，小球藻,布鲁尼肉毒杆菌和念珠菌作为潜在的外科缝合涂层材料。将它们的粗提物吸收到两种不同的缝合线中，如聚乙醇酸（90％）-共乳酸（10％）（PGLA）和聚二恶烷酮（PDO）；然后，他们的细胞毒作用和抗菌活性进行了检查。Muscorum包被的缝合线(PGLA和PDO)和Platensis包被的缝合线(PGLA和PDO)对L929小鼠成纤维细胞没有诱导任何毒性作用(>70%细胞活力)。对金黄色葡萄球菌具有最高的抗菌活性，和A.platensis涂层PGLA为11.18±0.54毫米，和9.52±1.15毫米，分别。这些缝合线通过机械分析进行了检查，并且根据ISO10993-5发现合适。与商业抗菌剂（氯己定）相比，结果证明，麝香草提取物可被认为是最有前途的人体缝合涂层材料。
