PDF(Pubmed)
Abstract：
The presence of alphaviruses, such as chikungunya virus (CHIKV), has never been reported in Mauritania. We assessed the seroprevalence of CHIKV among Nouakchott residents. A cross-sectional study involving 1300 non-febrile patients consulting at the Nouakchott hospital center was conducted between January and June 2021. The presence of anti-CHIKV IgG and neutralizing antibodies against CHIKV, O\'nyong-nyong virus (ONNV), and Semliki Forest virus (SFV) was determined by an enzyme-linked immunosorbent assay (ELISA) and a serum neutralization test, respectively, and the associated risk factors were investigated. Of the 1300 study participants, serological evidence of previous exposure to CHIKV was observed in 37 individuals (2.8%). Sex, age, reported use of repellants, and bed net ownership and usage were not associated with CHIKV seropositivity. Our results showed the co-circulation of two other alphaviruses, ONNV and SFV, in Nouakchott in 30 (2.3%) individuals. This is the first study that documents the co-circulation of CHIKV, ONNV, and SFV in Mauritania, albeit at low prevalence. Surveillance and routine testing for alphaviruses and other arboviruses in symptomatic patients should be implemented in health facilities to assess the health burden associated with these viruses. Efforts should also be made to strengthen the vector control measures.
摘要：
甲病毒的存在，例如基孔肯雅病毒（CHIKV），在毛里塔尼亚从未报道过。我们评估了努瓦克肖特居民中CHIKV的血清阳性率。2021年1月至6月间进行了一项横断面研究，涉及1300名非发热患者在努瓦克肖特医院中心咨询。抗CHIKVIgG和抗CHIKV的中和抗体的存在，O\'nyong-nyong病毒（ONNV），和Semliki森林病毒（SFV）通过酶联免疫吸附测定（ELISA）和血清中和试验，分别,并对相关危险因素进行调查。在1300名研究参与者中，在37例个体(2.8%)中观察到先前接触过CHIKV的血清学证据.性,年龄,据报道使用了驱虫剂，蚊帐拥有和使用与CHIKV血清阳性无关。我们的结果显示了另外两种甲病毒的共同循环，ONNV和SFV,在努瓦克肖特，有30人(2.3%)。这是第一个记录CHIKV共同发行的研究，ONNV,和毛里塔尼亚的SFV，尽管患病率较低。应在医疗机构实施对有症状患者的甲病毒和其他虫媒病毒的监测和常规检测，以评估与这些病毒相关的健康负担。还应努力加强病媒控制措施。
