PDF(Pubmed)
Abstract：
The incidence of gastrointestinal cancers has increased in recent years. Current treatments present numerous challenges, including drug resistance, non-specificity, and severe side effects, needing the exploration of new therapeutic strategies. One promising avenue is the use of magnetic nanoparticles, which have gained considerable interest due to their ability to generate heat in tumor regions upon the application of an external alternating magnetic field, a process known as hyperthermia. This review conducted a systematic search of in vitro and in vivo studies published in the last decade that employ hyperthermia therapy mediated by magnetic nanoparticles for treating gastrointestinal cancers. After applying various inclusion and exclusion criteria (studies in the last 10 years where hyperthermia using alternative magnetic field is applied), a total of 40 articles were analyzed. The results revealed that iron oxide is the preferred material for magnetism generation in the nanoparticles, and colorectal cancer is the most studied gastrointestinal cancer. Interestingly, novel therapies employing nanoparticles loaded with chemotherapeutic drugs in combination with magnetic hyperthermia demonstrated an excellent antitumor effect. In conclusion, hyperthermia treatments mediated by magnetic nanoparticles appear to be an effective approach for the treatment of gastrointestinal cancers, offering advantages over traditional therapies.
摘要：
近年来，胃肠道癌症的发病率有所增加。目前的治疗提出了许多挑战，包括耐药性,非特异性，和严重的副作用，需要探索新的治疗策略。一个有希望的途径是使用磁性纳米粒子，由于它们在施加外部交变磁场时能够在肿瘤区域产生热量，因此获得了相当大的兴趣，称为热疗的过程。这篇综述对最近十年发表的体外和体内研究进行了系统的搜索，这些研究采用磁性纳米颗粒介导的热疗治疗胃肠道癌症。在应用各种纳入和排除标准后（过去10年中使用替代磁场进行热疗的研究），共分析了40篇文章。结果表明，氧化铁是纳米颗粒中产生磁性的首选材料，大肠癌是研究最多的胃肠道癌症。有趣的是,新的治疗方法采用纳米粒子加载化疗药物，并结合磁性热疗显示出优异的抗肿瘤效果。总之,磁性纳米颗粒介导的热疗治疗似乎是治疗胃肠道癌症的有效方法，提供优于传统疗法的优势。
