PDF(Pubmed)
Abstract：
The low-bacterial diet (LBD) is a widely used dietary regimen to reduce the risk of food-borne infections in patients with neutropenic cancer, but its role is controversial due to its unclear benefits. The purpose of this study was to provide an updated analysis of the available evidence on the efficacy of the LBD to reduce the risk of infections, mortality rates, and quality of life (QoL) in neutropenic patients with cancer. A systematic literature search was conducted in the biomedical databases Cochrane Library, PubMed, CINHAL, and EMBASE. The process of the screening, selection, inclusion of articles, and assessment of risk of bias and methodological quality was conducted by two reviewers. Of the 1985 records identified, 12 were included. The LBD demonstrated heterogeneity in definition, composition, and initiation timing; moreover, the LBD did not demonstrate a reduction in infection and mortality rates compared to a free diet, showing a negative correlation with quality of life. The LBD, in addition to not bringing benefits in terms of reductions in infection and mortality rates, has been shown to worsen the quality of life due to the reduced palatability and limited variety of the food supply, negatively impacting nutritional status.
摘要：
低细菌饮食（LBD）是一种广泛使用的饮食方案，可降低中性粒细胞减少癌患者食源性感染的风险，但它的作用是有争议的，因为它的好处不清楚。这项研究的目的是提供有关LBD疗效的现有证据的最新分析，以降低感染风险，死亡率,中性粒细胞减少患者的生活质量（QoL）。在生物医学数据库CochraneLibrary中进行了系统的文献检索，PubMed,CINHAL,和EMBASE。筛选的过程，选择,包括文章，并由两名评审员对偏倚风险和方法学质量进行评估。在1985年确定的记录中，包括12个。LBD在定义上表现出异质性，composition,和启动时间；此外，与免费饮食相比，LBD的感染率和死亡率没有降低，与生活质量呈负相关。LBD,除了在降低感染率和死亡率方面没有带来好处之外，已被证明，由于适口性降低和食物供应的种类有限，生活质量恶化，对营养状况产生负面影响。
