PDF(Pubmed)
Abstract：
Full and partial restorations in dentistry must replicate the characteristics of the patient\'s natural teeth. Materials must have good mechanical properties and be non-toxic and biocompatible. Microbes, which can form biofilms, are constantly in contact with restorations. In this study, we investigate how well Candida albicans adheres to a polymethyl methacrylate (PMMA) resin base with gold (Au) nanoparticles. We synthesized Au nanoparticles and characterized them. The average size of Au nanoparticles embedded in PMMA was 11 nm. The color difference ΔE between PMMA and PMMA/Au composites was 2.7 and was still esthetically acceptable to patients. PMMA/Au surfaces are smoother and more hydrophilic than pure PMMA surfaces, and the isoelectric point of both types of surfaces was 4.3. Above the isoelectric point, PMMA/Au surfaces are more negatively charged than PMMA surfaces. The added Au nanoparticles decreased the tensile strength, while the hardness did not change significantly. Adhesion measurements showed that PMMA surfaces modified with Au nanoparticles reduced the extent of microbial adhesion of Candida albicans.
摘要：
牙科中的全部和部分修复必须复制患者天然牙齿的特征。材料必须具有良好的机械性能，并且无毒且具有生物相容性。微生物,可以形成生物膜，经常与修复体接触。在这项研究中,我们研究了白色念珠菌与金（Au）纳米颗粒的聚甲基丙烯酸甲酯（PMMA）树脂基质的粘附程度。我们合成了Au纳米粒子并对其进行了表征。嵌入PMMA中的Au纳米颗粒的平均尺寸为11nm。PMMA和PMMA/Au复合材料之间的色差ΔE为2.7，患者在美学上仍可接受。PMMA/Au表面比纯PMMA表面更光滑，更亲水，两种表面的等电点均为4.3。高于等电点,PMMA/Au表面比PMMA表面带负电。添加Au纳米颗粒降低了拉伸强度，而硬度没有明显变化。粘附测量表明，用Au纳米颗粒修饰的PMMA表面降低了白色念珠菌的微生物粘附程度。
