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Abstract：
Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former\'s chronic state of inflammation, and adverse pregnancy outcomes are no exception. As a result of periodontal pathogen invasion, a series of systemic inflammatory and immunologic events affecting the safety of the fetoplacental unit may unfold. This may be further exaggerated by physiologic hormonal and metabolic fluctuations during pregnancy. This can not only negatively affect the gestation period and consequently cause preterm low weight but also complicate the pregnancy via preeclampsia and gestational diabetes. This narrative review article aims to provide a summary of relevant available evidence pertinent to the relationship between periodontal diseases, associated periodontal pathogens and virulence mechanisms mediated by pro-inflammatory cytokines and prostaglandins, and adverse pregnancy outcomes. Furthermore, this article highlights some of the literature addressing the impact of periodontal therapy interventions and pregnancy outcomes.
摘要：
牙周病是牙齿支撑装置的多微生物感染，表现为临床附着丧失和牙槽骨丧失。由于牙周病的慢性炎症状态，文献中已经提出了牙周病与全身性疾病之间的关联。不良妊娠结局也不例外.由于牙周病原体的入侵，可能会发生一系列影响胎儿胎盘单元安全性的全身性炎症和免疫事件.怀孕期间的生理激素和代谢波动可能会进一步加剧这种情况。这不仅会对妊娠期产生负面影响，从而导致早产低体重，而且还会通过先兆子痫和妊娠糖尿病使妊娠复杂化。这篇叙述性综述文章旨在提供与牙周病之间关系相关的现有证据的摘要。相关的牙周病原体和由促炎细胞因子和前列腺素介导的毒力机制，和不良妊娠结局。此外，本文重点介绍了一些有关牙周治疗干预和妊娠结局影响的文献.
