PDF(Pubmed)
Abstract：
This study aims to systematise subfoveal choroidal thickness (SFCT) measured using optical coherence tomography (OCT) in patients with different severities of thyroid eye disease (TED) compared with healthy subjects. The PubMed, Web of Science and Scopus databases were searched for the following terms: ((Graves\' ophthalmopathy) OR (thyroid eye disease) OR (Graves\' orbitopathy) OR (thyroid-associated orbitopathy)) AND (choroidal thickness) AND ((optical coherence tomography) OR (OCT)). The pool of papers was narrowed down to articles published until 31 January 2023 (26, 26 and 96 papers, respectively). Twenty-five (25) articles were taken into consideration, which were original papers and included the choroidal thickness measurements among TED patients in their results. Finally, eight papers were included in the comparative analysis of the SFCT parameter in TED patients and a group of healthy controls, and seven papers in the comparative analysis of the same parameter between active and inactive TED patients. The mean value of the difference between the TED group and the healthy group was 38.79 μm, with a confidence interval (CI) from 0.09 to 77.49 μm (p = 0.0495). The mean difference between the active TED group and inactive TED group was 38.02 μm, with a CI from 8.62 to 67.42 μm (p = 0.0113). All the results were statistically significant.
摘要：
这项研究旨在将使用光学相干断层扫描（OCT）测量的不同严重程度的甲状腺眼病（TED）患者的中央凹下脉络膜厚度（SFCT）与健康受试者进行系统化。PubMed,在WebofScience和Scopus数据库中搜索以下术语：（（格雷夫斯眼病）或（甲状腺眼病）或（格雷夫斯眼病）或（甲状腺相关眼病））和（脉络膜厚度）和（（（光学相干断层扫描）或（OCT））。论文池缩小到2023年1月31日之前发表的文章(26、26和96篇论文，分别)。考虑了二十五(25)条，这是原始论文，并在他们的结果中包括TED患者的脉络膜厚度测量。最后,8篇论文被纳入TED患者和一组健康对照的SFCT参数的比较分析，和七篇论文对活跃和不活跃的TED患者之间的相同参数进行了比较分析。TED组与健康组差异的平均值为38.79μm,置信区间(CI)为0.09至77.49μm(p=0.0495)。活动TED组和非活动TED组之间的平均差异为38.02μm，aCI为8.62至67.42μm(p=0.0113)。所有结果均具有统计学意义。
