PDF(Pubmed)
Abstract：
Atopic dermatitis (AD) has been extensively investigated for genetic associations utilizing both candidate gene approaches and genome-wide scans. Here, we comprehensively evaluated the available literature to determine the association of candidate genes in AD to gain additional insight into the etiopathogenesis of the disease. We systematically screened all studies that explored the association between polymorphisms and AD risks in cases of European and Asian ancestry and synthesized the available evidence through a random-effects meta-analysis. We identified 99 studies that met our inclusion/exclusion criteria that examined 17 candidate loci in Europeans and 14 candidate genes in Asians. We confirmed the significant associations between FLG variants in both European and Asian populations and AD risk, while synthesis of the available data revealed novel loci mapped to IL18 and TGFB1 genes in Europeans and IL12RB1 and MIF in Asians that have not yet been identified by genome-wide association studies. Our findings provide comprehensive evidence for AD risk loci in cases of both European and Asian ancestries, validating previous associations as well as revealing novel loci that could imply previously unexplored biological pathways.
摘要：
已经利用候选基因方法和全基因组扫描对特应性皮炎（AD）的遗传关联进行了广泛的研究。这里,我们全面评估了现有文献,以确定AD中候选基因的相关性,从而进一步了解疾病的病因.我们系统地筛选了所有探索欧洲和亚洲血统病例中多态性与AD风险之间关联的研究，并通过随机效应荟萃分析综合了现有证据。我们确定了99项符合我们的纳入/排除标准的研究，这些研究检查了欧洲人的17个候选基因座和亚洲人的14个候选基因。我们证实了欧洲和亚洲人群的FLG变异与AD风险之间的显著关联，而现有数据的合成揭示了欧洲人中IL18和TGFB1基因以及亚洲人IL12RB1和MIF基因的新基因座，这些基因座尚未通过全基因组关联研究鉴定。我们的发现为欧洲和亚洲祖先的AD风险位点提供了全面的证据，验证先前的关联，并揭示可能暗示先前未探索的生物学途径的新基因座。
