PDF(Pubmed)
Abstract：
Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in activating naive T cells through presenting antigen information, thereby influencing immunity and anti-cancer responses. Fascin, a 55-kDa actin-bundling protein, is highly expressed in mature DCs and serves as a marker protein for their identification. However, the precise role of fascin in intratumoral DCs remains poorly understood. In this review, we aim to summarize the role of fascin in both normal and intratumoral DCs. In normal DCs, fascin promotes immune effects through facilitating DC maturation and migration. Through targeting intratumoral DCs, fascin inhibitors enhance anti-tumor immune activity. These roles of fascin in different DC populations offer valuable insights for future research in immunotherapy and strategies aimed at improving cancer treatments.
摘要：
树突状细胞（DCs）是专门的抗原呈递细胞，在通过呈递抗原信息激活幼稚T细胞中起关键作用，从而影响免疫和抗癌反应。Fascin,一种55kDa的肌动蛋白束蛋白，在成熟DCs中高度表达，并作为其鉴定的标记蛋白。然而,fascin在肿瘤内DCs中的确切作用尚不清楚.在这次审查中,我们的目的是总结fascin在正常和肿瘤内DCs中的作用。在正常DC中，Fascin通过促进DC成熟和迁移来促进免疫作用。通过靶向肿瘤内DCs，fascin抑制剂增强抗肿瘤免疫活性。fascin在不同DC人群中的这些作用为未来的免疫治疗研究和旨在改善癌症治疗的策略提供了有价值的见解。
