Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review.

小儿脑肿瘤微环境的免疫生物学和细胞因子调节 ： 范围综述。

• 影响指数: 6.575
• 发表时间: 2023 Jul 18
• 来源期刊: Cancers (Basel)
• DOI: 10.3390/cancers15143655
• PMID: 37509316
• 文章类型: Journal Article
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Budhiraja S,Najem H,Tripathi S,Wadhawani NR,Horbinski C,McCord M,Lenzen AC,Heimberger AB,DeCuypere M

关键词: immunotherapy; microenvironment; pediatric brain tumor; therapeutic strategies

Abstract

Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited efforts to date to characterize and understand the immunological aspects of tumor biology with an over-reliance on observations from the adult glioma population. Foundational knowledge regarding the frequency and ubiquity of immune therapeutic targets is an area of unmet need along with the development of immune-competent pediatric tumor models to test therapeutics and especially combinatorial treatment. Opportunities arise in the evolution of pediatric tumor classification from histological to molecular with targeted immune therapeutics.

摘要

利用免疫生物学领域的范围审查策略来识别免疫治疗靶标，评估了实施小儿脑肿瘤免疫治疗策略的知识差距.该分析表明，迄今为止，在过度依赖成人神经胶质瘤人群的观察结果的情况下，表征和理解肿瘤生物学的免疫学方面的努力有限。关于免疫治疗靶标的频率和普遍性的基础知识是一个未满足的需求领域，同时开发具有免疫能力的儿科肿瘤模型来测试治疗方法，尤其是组合治疗。在儿科肿瘤分类从组织学到具有靶向免疫治疗的分子的演变中出现了机会。