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Abstract：
The effects of concurrent optical and magnetic stimulation (COMS) therapy on wound-healing-related parameters, such as tissue oxygenation and water index, were analyzed by hyperspectral imaging: an exploratory case series. Background: Oedema and inadequate perfusion have been identified as key factors in delayed wound healing and have been linked to reduced mitochondrial respiration. Targeting mitochondrial dysfunction is a promising approach in the treatment of therapy refractory wounds. This sub-study aimed to investigate the effects of concurrent optical and magnetic stimulation (COMS) on oedema and perfusion through measuring tissue oxygenation and water index, using hyperspectral imaging. Patients and methods: In a multi-center, prospective, comparative clinical trial, eleven patients with chronic leg and foot ulcers were treated with COMS additively to Standard of Care (SOC). Hyperspectral images were collected during patient visits before and after treatment to assess short- and long-term hemodynamic and immunomodulatory effects through changes in tissue oxygenation and water index. Results: The average time for wound onset in the eleven patients analyzed was 183 days, with 64% of them being considered unresponsive to SOC. At week 12, the rate of near-complete and complete wound closure was 64% and 45%, respectively. COMS therapy with SOC resulted in an increased short-term tissue oxygenation over the 8-week treatment phase, with oxygen levels decreasing in-between patient visits. The study further found a decrease in tissue water content after the therapy, with a general accumulation of water levels in-between patient visits. This study\'s long-term analysis was hindered by the lack of absolute values in hyperspectral imaging and the dynamic nature of patient parameters during visits, resulting in high interpatient and intervisit variability. Conclusions: This study showed that COMS therapy as an adjunct to SOC had a positive short-term effect on inflammation and tissue oxygenation in chronic wounds of various etiologies. These results further supported the body of evidence for safety and effectiveness of COMS therapy as a treatment option, especially for stagnant wounds that tended to stay in the inflammatory phase and required efficient phase transition towards healing.
摘要：
光学和磁刺激（COMS）治疗对伤口愈合相关参数的影响，如组织氧合和水指数，通过高光谱成像进行了分析：一个探索性案例系列。背景：水肿和灌注不足已被确定为伤口愈合延迟的关键因素，并且与线粒体呼吸减少有关。靶向线粒体功能障碍是治疗难治性伤口的有希望的方法。这项子研究旨在通过测量组织氧合和水指数来研究同时进行的光学和磁刺激（COMS）对水肿和灌注的影响。使用高光谱成像。患者和方法：在多中心，prospective,比较临床试验,11例慢性腿部和足部溃疡患者接受了COMS治疗，并加入了标准护理（SOC）。在治疗前后患者访视期间收集高光谱图像，以通过组织氧合和水指数的变化评估短期和长期的血流动力学和免疫调节作用。结果：分析的11例患者的平均伤口发作时间为183天，其中64%被认为对SOC无反应。在第12周，伤口接近完全和完全闭合的比率分别为64％和45％，分别。在8周的治疗阶段，使用SOC的COMS治疗导致短期组织氧合增加。患者就诊之间的氧气水平降低。研究进一步发现治疗后组织含水量下降,在患者就诊之间，水位普遍积聚。本研究的长期分析受到高光谱成像中缺乏绝对值和访视期间患者参数的动态性质的阻碍。导致较高的患者间和互访变异性。结论：这项研究表明，COMS疗法作为SOC的辅助治疗对各种病因的慢性伤口的炎症和组织氧合具有积极的短期作用。这些结果进一步支持了COMS疗法作为治疗选择的安全性和有效性的大量证据。特别是对于倾向于停留在炎症阶段并需要有效的相变愈合的停滞伤口。
