PDF(Pubmed)
Abstract：
Tetracycline-class drugs are frequently used in dermatology for their anti-inflammatory properties to treat skin diseases such as acne, rosacea, and hidradenitis suppurativa (HS). The American Academy of Dermatology (AAD) clinical guidelines do not offer guidance regarding the co-administration of food with tetracycline-class drugs. The objectives of this study were to review the available evidence regarding whether taking tetracycline-class drugs with food decreases systemic absorption and is associated with an impact on clinical efficacy. A literature search was conducted using the PubMed database between February to May 2023 using the keywords \"tetracycline-class drugs\", \"pharmacokinetics\", \"absorption\", and \"dermatology\". Inclusion criteria included articles written in English and relevant to the absorption and efficacy of tetracycline-class drugs. This search yielded 131 articles written between 1977 to 2022, of which 29 met the criteria for review. United States Food and Drug Administration (FDA)-approved prescribing information for oral formulations of tetracycline, doxycycline, minocycline, and sarecycline were reviewed. Systemic absorption of tetracycline decreased when co-administered with food. Systemic absorption of oral doxycycline and minocycline was variable with food co-administration. The impact on bioavailability varied with the drug formulation and dosage. The absorption of oral sarecycline decreased when administered with food. Sarecycline is the only oral antibiotic where population pharmacokinetic studies demonstrated limited or no impact of food intake on clinical efficacy. There are no available data for other tetracycline-class drugs in dermatology. If patients find it more tolerable to take doxycycline, minocycline, and sarecycline with food to avoid gastrointestinal distress, this may merit consideration to encourage patient adherence. Since the impact of food intake on absorption varied with the dosage form of doxycycline and minocycline, consulting the appropriate package insert may give clinicians additional insight into differences in the various formulations.
摘要：
四环素类药物因其抗炎特性而经常用于皮肤科，以治疗痤疮等皮肤病。酒渣鼻,和化脓性汗腺炎（HS）。美国皮肤病学会（AAD）临床指南未提供有关食物与四环素类药物共同给药的指导。这项研究的目的是回顾有关食物中服用四环素类药物是否会减少全身吸收并对临床疗效产生影响的现有证据。在2023年2月至5月之间使用PubMed数据库使用关键词“四环素类药物”进行了文献检索，“药代动力学”，“吸收”，和“皮肤病学”。纳入标准包括用英语撰写的与四环素类药物的吸收和疗效相关的文章。这项搜索产生了1977年至2022年间撰写的131篇文章，其中29篇符合审查标准。美国食品和药物管理局（FDA）批准的四环素口服制剂的处方信息，多西环素,米诺环素,和sarcycline进行了审查。与食物共同给药时，四环素的全身吸收降低。口服多西环素和米诺环素的全身吸收随食物共同给药而变化。对生物利用度的影响随药物制剂和剂量而变化。当与食物一起服用时，口服香肠的吸收减少。Sarecycline是唯一的口服抗生素，其中人群药代动力学研究表明食物摄入对临床疗效的影响有限或没有影响。皮肤病学中没有其他四环素类药物的可用数据。如果患者发现服用多西环素更耐受，米诺环素,和sarcycline食物，以避免胃肠道不适，这可能值得考虑以鼓励患者坚持.由于食物摄入对吸收的影响因多西环素和米诺环素的剂型而异，查阅适当的包装说明书可以让临床医生更深入地了解各种配方的差异.
