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Abstract：
Triple-negative breast cancer (TNBC), which lacks the expression of the three hormone receptors (i.e., estrogen receptor, progesterone receptor, and human epidermal growth factor receptor), is characterized by a high proliferative index, high invasiveness, poor prognosis, early relapse, and a tendency to be present in advanced stages. These characteristics rank TNBC among the most aggressive and lethal forms of breast cancer. The lack of the three receptors renders conventional hormonal therapy ineffective against TNBC. Moreover, there are no clinically approved therapies that specifically target TNBC, and the currently used chemotherapeutic agents, such as cisplatin, taxanes, and other platinum compounds, have a limited clinical effect and develop chemoresistance over time. Phytochemicals have shown efficacy against several types of cancer, including TNBC, by targeting several pathways involved in cancer development and progression. In this review, we focus on one phytochemical carnosol, a natural polyphenolic terpenoid with strong anti-TNBC effects and its ROS-dependent molecular mechanisms of action. We discuss how carnosol targets key pathways and proteins regulating the cell cycle, growth, epigenetic regulators, invasion, and metastasis of TNBC. This review identifies carnosol as a potential novel targeting protein degradation molecule.
摘要：
三阴性乳腺癌（TNBC），缺乏三种激素受体的表达(即，雌激素受体，孕激素受体,和人表皮生长因子受体），其特征是高增殖指数，高侵袭性,预后不良,早期复发，以及处于高级阶段的趋势。这些特征将TNBC列为最具侵袭性和致死性的乳腺癌之一。三种受体的缺乏使得常规激素疗法对TNBC无效。此外，没有临床批准的专门针对TNBC的疗法，以及目前使用的化疗药物，如顺铂，紫杉烷,和其他铂化合物，具有有限的临床效果，并随着时间的推移发展化学耐药性。植物化学物质已经显示出对几种癌症的功效，包括TNBC,通过靶向参与癌症发展和进展的几种途径。在这次审查中,我们专注于一种植物化学物质，一种具有强抗TNBC作用的天然多酚萜类化合物及其依赖ROS的分子作用机制。我们讨论了鼠尾草酚如何靶向调节细胞周期的关键途径和蛋白质，增长,表观遗传调节因子，入侵,和TNBC的转移。本文将鼠尾草酚确定为一种潜在的新型靶向蛋白质降解分子。
