PDF(Pubmed)
Abstract：
Elderly dogs are steadily increasing worldwide as well as veterinarians\' and owners\' interest in their health and wellness. Aging is not a disease, but a combination of changes negatively affecting the organism in general and the immune system in particular, resulting in a decline in protection over time. The aim of this study was to measure the specific serum antibody titers against the main dangerous and widespread viral diseases preventable by core vaccinations in senior and geriatric dogs using the in-practice test VacciCheck. A cohort of three hundred fifty elderly dogs was analyzed for Protective Antibody Titers (PATs) against CPV-2, CDV and CAdV-1. The age ranged from 5 to 19 years, with two hundred fifty-eight seniors (73.7%) and ninety-two geriatrics (26.3%), and 97.4% of them were vaccinated at least once in their lives. More than half of the entire study population (52.9%) had PATs simultaneously for all three diseases, with 80.5% seniors and 19.5% geriatrics. Specific PATs were found in 88.6% of aging dogs for CPV-2, 82.3% for CadV-1 and 66.0% for CDV, demonstrating that unprotected aging dogs represent a minority. Unexpectedly, the larger elderly dogs resulted as more protected than smaller ones for CPV-2. Protection then decreases over time, with geriatric dogs less protected than senior ones. Veterinary practitioners should therefore always consider whether to maintain core vaccinations in aging dogs as in adults on a three-year basis or opt instead for closer boosters (every 1 or 2 years). PATs for core vaccines could then represent a good biomarker of protection and their titration could become a standard of care, especially in such a sensitive period of the dogs\' life.
摘要：
在全球范围内，老年犬以及兽医和主人对其健康和保健的兴趣正在稳步增加。衰老不是一种疾病，但是这些变化的组合会对整个生物体，特别是免疫系统产生负面影响，导致保护随着时间的推移而下降。这项研究的目的是使用实践测试VacciCheck测量针对高级和老年犬的核心疫苗接种可预防的主要危险和广泛的病毒性疾病的特异性血清抗体滴度。分析了三百五十只老年犬的群体针对CPV-2、CDV和CAdV-1的保护性抗体滴度(PAT)。年龄从5岁到19岁，有二百五十八个老年人(73.7%)和92个老年病科(26.3%)，97.4%的人一生中至少接种过一次疫苗。超过一半的整个研究人群（52.9％）同时患有所有三种疾病的PAT，有80.5%的老年人和19.5%的老年病学。在CPV-2的88.6％，CadV-1的82.3％和CDV的66.0％的衰老犬中发现了特定的PAT，证明无保护的衰老犬只占少数。出乎意料的是,对于CPV-2，较大的老年犬比较小的犬受到更多保护。保护随着时间的推移而减少，老年犬的保护程度比老年犬低。因此，兽医应始终考虑是否在三年的基础上保持成年犬的核心疫苗接种，或者选择更紧密的助推器（每1或2年）。然后，核心疫苗的PAT可以代表良好的保护生物标志物，它们的滴定可以成为护理标准，特别是在这样一个敏感时期的狗\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\
