PDF(Pubmed)
Abstract：
Trichothecenes are the most common Fusarium toxins detected in grains and related products. Type A trichothecenes are among the mycotoxins of greatest concern to food and feed safety due to their high toxicity. Recently, two different trichothecene genotypes within Fusarium species were reported. The available information showed that Tri1 and Tri16 genes are the key determinants of the trichothecene profiles of T-2 and DAS genotypes. In this review, polymorphisms in the Tri1 and Tri16 genes in the two genotypes were investigated. Meanwhile, the functions of genes involved in DAS and NEO biosynthesis are discussed. The possible biosynthetic pathways of DAS and NEO are proposed in this review, which will facilitate the understanding of the synthesis process of trichothecenes in Fusarium strains and may also inspire researchers to design and conduct further research. Together, the review provides insight into trichothecene profile differentiation and Tri gene evolutionary processes responsible for the structural diversification of trichothecene produced by Fusarium.
摘要：
三端孢霉烯是在谷物和相关产品中检测到的最常见的镰刀菌毒素。A型单端孢霉烯是对食品和饲料安全最关注的真菌毒素之一，因为它们具有高毒性。最近,据报道，镰刀菌属中有两种不同的单端孢菌基因型。现有信息表明，Tri1和Tri16基因是T-2和DAS基因型的单端囊菌谱的关键决定因素。在这次审查中,研究了两种基因型中Tri1和Tri16基因的多态性。同时,讨论了参与DAS和NEO生物合成的基因的功能。本文提出了DAS和NEO可能的生物合成途径，这将有助于了解镰刀菌菌株中单端孢霉烯的合成过程，也可能激发研究人员设计和进行进一步的研究。一起,该综述提供了有关由镰刀菌产生的单端孢霉烯的结构多样化的三端基因进化过程的见解。
