Abstract：
Sarcoidosis is a systemic inflammatory disorder characterized by tissue infiltration due to mononuclear phagocytes and lymphocytes and associated noncaseating granuloma formation. Pulmonary sarcoidosis (PS) shares a number of clinical, radiological, and histopathological characteristics with that of pulmonary tuberculosis (PTB). Due to this, clinicians face issues in differentiating between PS and PTB in a substantial number of cases. There is a lack of any specific biomarker that can diagnose PS distinctively from PTB. We compared T-cell-based signature cytokines in patients with PS and PTB. In this study, we proposed a serum biomarker panel consisting of cytokines from cells: T helper (Th) 1 [interferon-gamma (IFN-γ); tumor necrosis factor-alpha (TNF-α)], Th9 [interleukin (IL)-9], Th17 [IL-17], and T regulatory (Treg) [IL-10; transforming growth factor-beta (TGF-β)]. We performed the principal component analysis that demonstrated that our serum cytokine panel has a significant predictive ability to differentiate PS from PTB. Our results could aid clinicians to improve the diagnostic workflow for patients with PS in TB endemic settings where the diagnosis between PS and PTB is often ambiguous.
摘要：
结节病是一种全身性炎症性疾病，其特征是由于单核吞噬细胞和淋巴细胞引起的组织浸润以及相关的非干酪性肉芽肿形成。肺结节病(PS)在临床上有许多共同点，放射学,以及与肺结核（PTB）的组织病理学特征。由于这个原因,在大量病例中，临床医生在区分PS和PTB方面面临问题。缺乏任何可以与PTB区别地诊断PS的特异性生物标志物。我们比较了PS和PTB患者中基于T细胞的特征细胞因子。在这项研究中,我们提出了一个由来自细胞的细胞因子组成的血清生物标志物组：T辅助（Th）1[干扰素-γ（IFN-γ）;肿瘤坏死因子-α（TNF-α）]，Th9[白细胞介素（IL）-9]，Th17[IL-17]，和T调节(Treg)[IL-10;转化生长因子-β(TGF-β)]。我们进行了主成分分析，证明我们的血清细胞因子组具有区分PS和PTB的显着预测能力。我们的结果可以帮助临床医生改善结核病流行环境中PS患者的诊断工作流程，其中PS和PTB之间的诊断通常不明确。
