Abstract：
Chagas disease in solid organ transplant recipients may present as a primary infection (PI). Early detection is crucial for timely treatment. This is the largest observational multicentre study evaluating qPCR for early diagnosis and treatment monitoring of PI in seronegative recipients of organs from seropositive donors. Of 34 patients admitted at 5 health centers, PI was detected by qPCR in 8 (23.5%) within a posttransplant period of 40 days (interquartile range [IQR], 31-50 days). No PI was detected by the Strout test or clinical symptoms/signs. All patients had favorable treatment outcome with negative qPCR 31 days (IQR, 18-35 days) after treatment, with no posttreatment relapse episodes.
摘要：
实体器官移植受者的恰加斯病可能表现为原发性感染（PI）。早期发现对于及时治疗至关重要。这是最大的观察性多中心研究，评估qPCR对血清阳性供体器官的血清阴性受体中PI的早期诊断和治疗监测。在5个健康中心收治的34名患者中，在40天的移植后期间，通过qPCR在8（23.5％）中检测到PI（四分位距[IQR]，31-50天）。通过Strout测试或临床症状/体征未检测到PI。所有患者均有良好的治疗结果，qPCR阴性31天（IQR，18-35天)治疗后，没有治疗后复发。
