PDF(Pubmed)
Abstract：
Existing cross-sectional and retrospective studies were unable to establish a causal relationship between psoriasis and cutaneous melanoma (CM). We sought to evaluate the causal role between psoriasis and CM.
We performed a bidirectional two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of psoriasis and CM among individuals of predominantly European ancestry. Mendelian randomization-Egger regression, inverse variance weighting, Mendelian Randomization Pleiotropy RESidual Sum and Outlier, weighted mode, and weighted median were used to examine the causal effect between psoriasis and CM.
Genetically predicted psoriasis was a significant risk factor for CM (odds ratio, 1.69; 95% confidence interval, 1.15-2.48; P = 0.025). In contrast, no association was observed between genetically predicted CM and psoriasis.
Our findings corroborated the existence of genetically predicted psoriasis increases risk of CM. Enhanced early screening of cutaneous melanoma in patients with psoriasis may improve clinical burden. However, we did not find evidence for a causal link from CM to psoriasis, so further studies are required to elucidate the effect of CM activity on psoriasis.
We performed a bidirectional two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of psoriasis and CM among individuals of predominantly European ancestry. Mendelian randomization-Egger regression, inverse variance weighting, Mendelian Randomization Pleiotropy RESidual Sum and Outlier, weighted mode, and weighted median were used to examine the causal effect between psoriasis and CM.
Genetically predicted psoriasis was a significant risk factor for CM (odds ratio, 1.69; 95% confidence interval, 1.15-2.48; P = 0.025). In contrast, no association was observed between genetically predicted CM and psoriasis.
Our findings corroborated the existence of genetically predicted psoriasis increases risk of CM. Enhanced early screening of cutaneous melanoma in patients with psoriasis may improve clinical burden. However, we did not find evidence for a causal link from CM to psoriasis, so further studies are required to elucidate the effect of CM activity on psoriasis.
摘要：
现有的横断面和回顾性研究无法确定牛皮癣和皮肤黑色素瘤（CM）之间的因果关系。我们试图评估银屑病和CM之间的因果关系。
我们使用来自以欧洲血统为主的个体的银屑病和CM的全基因组关联研究的汇总统计进行了双向双样本孟德尔随机化分析。孟德尔随机化-Egger回归，方差倒数加权，孟德尔随机化多效性RESidualSum和离群值，加权模式，和加权中位数用于检查银屑病和CM之间的因果关系。
遗传预测的银屑病是CM的重要危险因素(比值比，1.69；95%置信区间，1.15-2.48；P=0.025）。相比之下,在遗传预测的CM和银屑病之间没有观察到相关性。
我们的发现证实了遗传预测的牛皮癣的存在会增加CM的风险。增强银屑病患者皮肤黑色素瘤的早期筛查可能会改善临床负担。然而,我们没有找到从CM到牛皮癣的因果关系的证据，因此，需要进一步的研究来阐明CM活性对银屑病的影响。
我们使用来自以欧洲血统为主的个体的银屑病和CM的全基因组关联研究的汇总统计进行了双向双样本孟德尔随机化分析。孟德尔随机化-Egger回归，方差倒数加权，孟德尔随机化多效性RESidualSum和离群值，加权模式，和加权中位数用于检查银屑病和CM之间的因果关系。
遗传预测的银屑病是CM的重要危险因素(比值比，1.69；95%置信区间，1.15-2.48；P=0.025）。相比之下,在遗传预测的CM和银屑病之间没有观察到相关性。
我们的发现证实了遗传预测的牛皮癣的存在会增加CM的风险。增强银屑病患者皮肤黑色素瘤的早期筛查可能会改善临床负担。然而,我们没有找到从CM到牛皮癣的因果关系的证据，因此，需要进一步的研究来阐明CM活性对银屑病的影响。
