Abstract：
The aim of the study was to assess the effect of non-surgical periodontal therapy (NSPT) on periodontal and cardiac parameters as well as on the expression of calprotectin and periostin levels in periodontitis patients with and without coronary artery disease (CAD).
Ninety subjects were categorised into three groups: Group H: periodontally and systemically healthy subjects, Group P: stage III grade B periodontitis subjects with no associated systemic diseases and Group P + CAD: stage III grade B periodontitis subjects diagnosed with CAD. Demographic, periodontal and cardiac parameters were recorded at baseline (0 day) and on the 180th day after NSPT. Gingival crevicular fluid was collected from all participants at baseline (0 day) and after the 180th day. Calprotectin and periostin expression were reassessed.
A significant increase in the levels of calprotectin (34.05 ± 11.72) was seen at baseline in the P + CAD group, whereas on the contrary, a decreased periostin (1.59 ± 0.41) was also noted at baseline. The study also showed a significant improvement in periodontal and cardiac parameters on the 180th day following NSPT.
Detection of calprotectin and periostin expression in GCF samples could represent a link to the association of periodontitis and CAD.
Ninety subjects were categorised into three groups: Group H: periodontally and systemically healthy subjects, Group P: stage III grade B periodontitis subjects with no associated systemic diseases and Group P + CAD: stage III grade B periodontitis subjects diagnosed with CAD. Demographic, periodontal and cardiac parameters were recorded at baseline (0 day) and on the 180th day after NSPT. Gingival crevicular fluid was collected from all participants at baseline (0 day) and after the 180th day. Calprotectin and periostin expression were reassessed.
A significant increase in the levels of calprotectin (34.05 ± 11.72) was seen at baseline in the P + CAD group, whereas on the contrary, a decreased periostin (1.59 ± 0.41) was also noted at baseline. The study also showed a significant improvement in periodontal and cardiac parameters on the 180th day following NSPT.
Detection of calprotectin and periostin expression in GCF samples could represent a link to the association of periodontitis and CAD.
摘要：
目的：本研究的目的是评估非手术牙周治疗（NSPT）对牙周炎患者的牙周和心脏参数以及钙卫蛋白和骨膜蛋白表达水平的影响有或无冠状动脉疾病（CAD）。
方法：将90名受试者分为三组：H组：牙周健康和全身健康的受试者，P组:无相关全身性疾病的III级B级牙周炎受试者,P+CAD组:诊断为CAD的III级B级牙周炎受试者。人口统计,在基线(0天)和NSPT后第180天记录牙周和心脏参数.在基线(0天)和第180天之后从所有参与者收集牙龈沟液。重新评估钙卫蛋白和骨膜素的表达。
结果：在P+CAD组中，基线时钙卫蛋白水平显著增加（34.05±11.72），相反，基线时骨膜蛋白也降低(1.59±0.41).该研究还显示，在NSPT后第180天，牙周和心脏参数显着改善。
结论：检测GCF样本中钙卫蛋白和骨膜素的表达可能与牙周炎和CAD的关联有关。
方法：将90名受试者分为三组：H组：牙周健康和全身健康的受试者，P组:无相关全身性疾病的III级B级牙周炎受试者,P+CAD组:诊断为CAD的III级B级牙周炎受试者。人口统计,在基线(0天)和NSPT后第180天记录牙周和心脏参数.在基线(0天)和第180天之后从所有参与者收集牙龈沟液。重新评估钙卫蛋白和骨膜素的表达。
结果：在P+CAD组中，基线时钙卫蛋白水平显著增加（34.05±11.72），相反，基线时骨膜蛋白也降低(1.59±0.41).该研究还显示，在NSPT后第180天，牙周和心脏参数显着改善。
结论：检测GCF样本中钙卫蛋白和骨膜素的表达可能与牙周炎和CAD的关联有关。
