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Abstract：
Objectives: To study the prevalence and the association of HPV infection in retinoblastoma and to determine the most common genotype presented in RB. Methods: Following the PRIMSA guideline, 14 studies reporting HPV infection in RB acquired from six databases were included. Results: The prevalence of HPV from 941 RB samples was 15.6% [95% confidence interval (CI): 7.3-30]. Mexico followed by India and Brazil had the highest HPV prevalence in RB samples, 61.7% (95% CI: 17-93), 22.5% (95% CI: 9-47), and 12.1% (95% CI: 2-52), in order. HPV 16 was the most common genotype presented in RB samples 23% (95% CI: 9-47), followed by HPV 18 10% (95% CI: 3-30) and the combined HPV 16-18 6% (95% CI: 0-50). We did not find a significant association between HPV and RB [odds ratio (OR): 12.2; 95% CI: 0.65-232; p = 0.09]. However, after removing the largest-weighted study, a significant association between HPV and RB was observed (OR: 45.9; 95% CI; 8.6-245; p < 0.001). Conclusion: HPV prevalence in RB samples was 15% and HPV 16 was the most presented genotype in RB samples. There may be an association between HPV and RB that is needed to be confirmed by high quality future studies. Preventive and treatment measures against HPV infection are essential for the prevention of any possible consequences, in particular, RB.
摘要：
目的：研究视网膜母细胞瘤中HPV感染的患病率和相关性，并确定RB中最常见的基因型。方法：遵循PRIMSA指南，包括从六个数据库获得的14项报告RB中HPV感染的研究。结果：941例RB样本中HPV的患病率为15.6％[95％置信区间（CI）：7.3-30]。墨西哥其次是印度和巴西，在RB样本中HPV患病率最高。61.7%（95%CI：17-93），22.5%（95%CI：9-47），和12.1%（95%CI：2-52），按顺序。HPV16是RB样本中最常见的基因型，23%(95%CI:9-47)，其次是HPV1810％（95％CI：3-30）和合并的HPV16-186％（95％CI：0-50）。我们没有发现HPV和RB之间的显著关联[比值比（OR）：12.2;95％CI：0.65-232;p=0.09]。然而,在删除最大加权研究后，观察到HPV和RB之间存在显著关联(OR:45.9;95%CI;8.6-245;p<0.001).结论：RB样本中HPV的患病率为15％，RB样本中HPV16是最常见的基因型。HPV和RB之间可能存在关联，需要通过高质量的未来研究来证实。针对HPV感染的预防和治疗措施对于预防任何可能的后果至关重要，特别是,RB。
