PDF(Pubmed)
Abstract：
UNASSIGNED: To compare the recent efficacy and safety of different Amplatzer models and similar occluder in the treatment of patent foramen ovale (PFO).
UNASSIGNED: Patients with PFO complicated with cryptogenic stroke or migraine who underwent transcatheter closure of PFO in the First Affiliated Hospital of Nanjing Medical University from September 2019 to March 2021 were selected. Patients were grouped according to the type of occluder device. The basic data of the patients were collected and followed up within 1 year after occlusion. Effectiveness was defined as no recurrence of stroke/remission of migraine symptoms and a negative postoperative foaming test, and safety events were counted as the combined results of serious adverse events.
UNASSIGNED: A total of 92 patients were selected, including 45 cases in the symmetrical group and 47 cases in the asymmetric group. There were no serious adverse events in the 2 groups during follow-up. 3 days and 1 month after occlusion, the number of shunt patients in the asymmetric group was significantly less than that in the symmetric group (χ2 = 5.484, P = 0.019; χ2 = 5.146, P = 0.023). The negative rate of blocked residual shunts in the asymmetric group was higher than that in the symmetric group at 1, 3, 6 and 12 months after occlusion (χ2 = 6.473, P = 0.011; χ2 = 4.305, P = 0.038; χ2 = 4.842, P = 0.027; χ2 = 4.034, P = 0.045). Headache in migraine patients in the asymmetric group was significantly better than headache in patients in the symmetric group (P = 0.038; P = 0.049).
UNASSIGNED: Asymmetric Amplatzer and similar occluders provide greater efficacy in short-term occlusion than symmetric ones.
UNASSIGNED: Patients with PFO complicated with cryptogenic stroke or migraine who underwent transcatheter closure of PFO in the First Affiliated Hospital of Nanjing Medical University from September 2019 to March 2021 were selected. Patients were grouped according to the type of occluder device. The basic data of the patients were collected and followed up within 1 year after occlusion. Effectiveness was defined as no recurrence of stroke/remission of migraine symptoms and a negative postoperative foaming test, and safety events were counted as the combined results of serious adverse events.
UNASSIGNED: A total of 92 patients were selected, including 45 cases in the symmetrical group and 47 cases in the asymmetric group. There were no serious adverse events in the 2 groups during follow-up. 3 days and 1 month after occlusion, the number of shunt patients in the asymmetric group was significantly less than that in the symmetric group (χ2 = 5.484, P = 0.019; χ2 = 5.146, P = 0.023). The negative rate of blocked residual shunts in the asymmetric group was higher than that in the symmetric group at 1, 3, 6 and 12 months after occlusion (χ2 = 6.473, P = 0.011; χ2 = 4.305, P = 0.038; χ2 = 4.842, P = 0.027; χ2 = 4.034, P = 0.045). Headache in migraine patients in the asymmetric group was significantly better than headache in patients in the symmetric group (P = 0.038; P = 0.049).
UNASSIGNED: Asymmetric Amplatzer and similar occluders provide greater efficacy in short-term occlusion than symmetric ones.
摘要：
■比较不同Amplatzer模型和类似封堵器治疗卵圆孔未闭（PFO）的近期疗效和安全性。
■选择2019年9月至2021年3月在南京医科大学第一附属医院行PFO封堵术的PFO合并隐源性卒中或偏头痛患者。根据封堵器装置的类型对患者进行分组。收集患者的基本资料，并在闭塞后1年内进行随访。有效性定义为无卒中复发/偏头痛症状缓解和术后泡沫试验阴性。和安全性事件被视为严重不良事件的综合结果.
■共选择了92名患者，其中对称组45例，不对称组47例。两组随访期间均未发生严重不良事件。闭塞后3天和1个月，不对称组的分流人数明显少于对称组（χ2=5.484，P=0.019；χ2=5.146，P=0.023）。闭塞后1、3、6、12个月，不对称组闭塞残余分流的阴性率高于对称组（χ2=6.473，P=0.011；χ2=4.305，P=0.038；χ2=4.842，P=0.027；χ2=4.034，P=0.045）。不对称组偏头痛患者的头痛明显优于对称组患者的头痛（P=0.038；P=0.049）。
■不对称Amplatzer和类似的封堵器在短期封堵中比对称封堵器提供更大的功效。
■选择2019年9月至2021年3月在南京医科大学第一附属医院行PFO封堵术的PFO合并隐源性卒中或偏头痛患者。根据封堵器装置的类型对患者进行分组。收集患者的基本资料，并在闭塞后1年内进行随访。有效性定义为无卒中复发/偏头痛症状缓解和术后泡沫试验阴性。和安全性事件被视为严重不良事件的综合结果.
■共选择了92名患者，其中对称组45例，不对称组47例。两组随访期间均未发生严重不良事件。闭塞后3天和1个月，不对称组的分流人数明显少于对称组（χ2=5.484，P=0.019；χ2=5.146，P=0.023）。闭塞后1、3、6、12个月，不对称组闭塞残余分流的阴性率高于对称组（χ2=6.473，P=0.011；χ2=4.305，P=0.038；χ2=4.842，P=0.027；χ2=4.034，P=0.045）。不对称组偏头痛患者的头痛明显优于对称组患者的头痛（P=0.038；P=0.049）。
■不对称Amplatzer和类似的封堵器在短期封堵中比对称封堵器提供更大的功效。
