Abstract：
BACKGROUND: The aim of the study was to investigate the relationship between systemic immune-inflammation index (SII) and early allograft dysfunction (EAD) and 90-day mortality after liver transplantation (LT) in acute-on-chronic liver failure (ACLF).
METHODS: Retrospective record analysis was done on 114 patients who had LT for ACLF. To identify the ideal SII, the receiver operating characteristic curve was used. The incidence of EAD and 90-day mortality following LT were calculated. The prognostic value of SII was assessed using the Kaplan-Meier technique and the Cox proportional hazards model.
RESULTS: The cut-off for SII was 201.5 (AUC = 0.728, p < 0.001). EAD occurred in 40 (35.1%) patients of the high SII group and 5 (4.4%) patients of the normal SII group, p < 0.001. 18 (15.8%) deaths occurred in the high SII group and 2 (1.8%) deaths occurred in the normal SII group, p = 0.008. The multivariate analysis demonstrated that SII ≥201.5, MELD ≥27 were independent prognostic factors for 90-day mortality after LT.
CONCLUSIONS: SII predicts the occurrence of EAD and is an independent risk factor for 90-day mortality after LT.
METHODS: Retrospective record analysis was done on 114 patients who had LT for ACLF. To identify the ideal SII, the receiver operating characteristic curve was used. The incidence of EAD and 90-day mortality following LT were calculated. The prognostic value of SII was assessed using the Kaplan-Meier technique and the Cox proportional hazards model.
RESULTS: The cut-off for SII was 201.5 (AUC = 0.728, p < 0.001). EAD occurred in 40 (35.1%) patients of the high SII group and 5 (4.4%) patients of the normal SII group, p < 0.001. 18 (15.8%) deaths occurred in the high SII group and 2 (1.8%) deaths occurred in the normal SII group, p = 0.008. The multivariate analysis demonstrated that SII ≥201.5, MELD ≥27 were independent prognostic factors for 90-day mortality after LT.
CONCLUSIONS: SII predicts the occurrence of EAD and is an independent risk factor for 90-day mortality after LT.
摘要：
背景：探讨全身免疫-炎症指数（SII）与急性对慢性肝衰竭（ACLF）肝移植后早期移植功能障碍（EAD）和90天死亡率之间的关系。
方法：对114例接受LT治疗的ACLF患者进行回顾性分析。为了确定理想的SII，使用受试者工作特征(ROC)曲线。计算LT后EAD的发生率和90天死亡率。使用Kaplan-Meier技术和Cox比例风险模型评估SII的预后价值。
结果：SII的临界值为201.5（AUC=0.728，P<0.001）。高SII组40例(35.1%)患者和正常SII组5例(4.4%)患者发生EAD,P<0.001。高SII组发生18例（15.8%）死亡，正常SII组发生2例（1.8%）死亡。P=0.008。多因素分析表明，SII≥201.5，MELD≥27是LT术后90天死亡率的独立预后因素。
结论：SII可预测EAD的发生，是LT术后90天死亡率的独立危险因素。
方法：对114例接受LT治疗的ACLF患者进行回顾性分析。为了确定理想的SII，使用受试者工作特征(ROC)曲线。计算LT后EAD的发生率和90天死亡率。使用Kaplan-Meier技术和Cox比例风险模型评估SII的预后价值。
结果：SII的临界值为201.5（AUC=0.728，P<0.001）。高SII组40例(35.1%)患者和正常SII组5例(4.4%)患者发生EAD,P<0.001。高SII组发生18例（15.8%）死亡，正常SII组发生2例（1.8%）死亡。P=0.008。多因素分析表明，SII≥201.5，MELD≥27是LT术后90天死亡率的独立预后因素。
结论：SII可预测EAD的发生，是LT术后90天死亡率的独立危险因素。
