Abstract：
Frey syndrome (FS) is a typical late complication following parotidectomy. Parotid surgery without proper coverage or reconstruction of exposed parotid parenchyma may contribute to the development of FS. Therefore, this study compared the closure versus the non-closure of exposed parotid parenchyma in the occurrence of FS.
This study included 195 patients with parotid lesions who underwent partial or superficial parotidectomy plus closure or non-closure of exposed parotid parenchyma, both with the application of fibrin glue. Two surgical methods of closure and non-closure were allocated to patients without randomization and blinding processes. The primary outcome was FS, and the second outcome was other complication rates.
The closure and non-closure of exposed parotid parenchyma were performed in 102 and 93 patients, respectively. Early postoperative complications occurred with temporary events: transient facial weakness, 32 (16.4%); hematoma, 13 (6.7%); and wound infection, 2 (1.0%), without statistical difference between the two groups (P > 0.1). However, sialocele occurred in the non-closure group (n = 19) more than in the closure group (n = 7) (P = 0.005). In the first postoperative year, decreased sensation and local pain were found in 16 patients (8.2%) and 9 patients (4.6%), respectively, with no statistical difference between the two groups (P > 0.1). FS was found more in the non-closure group (n = 19, 20.4%) than in the closure group (n = 4, 3.9%) (P < 0.001).
The closure of exposed parotid parenchyma and covering fascia is preferred over the non-closure to prevent FS.
This study included 195 patients with parotid lesions who underwent partial or superficial parotidectomy plus closure or non-closure of exposed parotid parenchyma, both with the application of fibrin glue. Two surgical methods of closure and non-closure were allocated to patients without randomization and blinding processes. The primary outcome was FS, and the second outcome was other complication rates.
The closure and non-closure of exposed parotid parenchyma were performed in 102 and 93 patients, respectively. Early postoperative complications occurred with temporary events: transient facial weakness, 32 (16.4%); hematoma, 13 (6.7%); and wound infection, 2 (1.0%), without statistical difference between the two groups (P > 0.1). However, sialocele occurred in the non-closure group (n = 19) more than in the closure group (n = 7) (P = 0.005). In the first postoperative year, decreased sensation and local pain were found in 16 patients (8.2%) and 9 patients (4.6%), respectively, with no statistical difference between the two groups (P > 0.1). FS was found more in the non-closure group (n = 19, 20.4%) than in the closure group (n = 4, 3.9%) (P < 0.001).
The closure of exposed parotid parenchyma and covering fascia is preferred over the non-closure to prevent FS.
摘要：
背景：Frey综合征（FS）是腮腺切除术后典型的晚期并发症。没有适当覆盖或重建暴露的腮腺实质的腮腺手术可能有助于FS的发展。因此,这项研究比较了在FS发生时暴露腮腺实质的闭合和不闭合.
方法：这项研究包括195例腮腺病变患者，这些患者接受了部分或浅表腮腺切除术，并封闭或不封闭暴露的腮腺实质，两者都与纤维蛋白胶的应用。将闭合和非闭合的两种手术方法分配给没有随机和盲法过程的患者。主要结果是FS，第二个结果是其他并发症发生率。
结果：分别在102例和93例患者中对暴露的腮腺实质进行了闭合和不闭合，分别。术后早期并发症与暂时性事件一起发生：短暂性面部无力，32（16.4%）；血肿，13（6.7％）；伤口感染，2（1.0%），两组间无统计学差异(P>0.1)。然而,非闭合组（n=19）比闭合组（n=7）更多（P=0.005）。在术后第一年，16例(8.2%)和9例(4.6%)感觉下降和局部疼痛,分别,两组间无统计学差异(P>0.1)。非闭合组（n=19，20.4%）的FS高于闭合组（n=4，3.9%）（P<0.001）。
结论：对暴露的腮腺实质和覆盖筋膜的闭合比非闭合更可取，以防止FS。
方法：这项研究包括195例腮腺病变患者，这些患者接受了部分或浅表腮腺切除术，并封闭或不封闭暴露的腮腺实质，两者都与纤维蛋白胶的应用。将闭合和非闭合的两种手术方法分配给没有随机和盲法过程的患者。主要结果是FS，第二个结果是其他并发症发生率。
结果：分别在102例和93例患者中对暴露的腮腺实质进行了闭合和不闭合，分别。术后早期并发症与暂时性事件一起发生：短暂性面部无力，32（16.4%）；血肿，13（6.7％）；伤口感染，2（1.0%），两组间无统计学差异(P>0.1)。然而,非闭合组（n=19）比闭合组（n=7）更多（P=0.005）。在术后第一年，16例(8.2%)和9例(4.6%)感觉下降和局部疼痛,分别,两组间无统计学差异(P>0.1)。非闭合组（n=19，20.4%）的FS高于闭合组（n=4，3.9%）（P<0.001）。
结论：对暴露的腮腺实质和覆盖筋膜的闭合比非闭合更可取，以防止FS。
