Abstract：
UNASSIGNED: To measure the macular pigment optical density in first-degree relatives of patients with age-related macular degeneration and compare it with a healthy control group.
UNASSIGNED: One hundred and twenty-eight healthy subjects who were first-degree relatives of age-related macular degeneration patients were included in the study (Group 1). As the control group, 74 healthy subjects were included in the study (Group 2). The right eyes of all cases were included in the study. Macular pigment optical density was measured with a commercially available device (MPSII®, Elektron Technology, Switzerland) using technology based on heterochromatic flicker photometry. Central foveal thickness and subfoveal choroidal thickness were measured with spectral-domain optical coherence tomography. Values were compared between the two groups.
UNASSIGNED: There were 54 males and 74 females in Group 1 and 32 males and 42 females in Group 2. The mean ± SD ages of Group 1 and Group 2 were 49.0 ± 7.6 and 41.8 ± 8.6, respectively. Mean ± SD macular pigment optical density values of Group 1 and Group 2 were 0.43 ± 0.09 and 0.47 ± 0.12 (p = 0.048), mean ± SD central foveal thickness were 208 ± 19 and 216 ± 8 µm (p = 0.014), and mean ± SD subfoveal choroidal thickness were 232 ± 29 and 250 ± 21 µm (p = 0.002), respectively.
UNASSIGNED: The macular pigment optical density values were significantly lower in the first-degree relatives of patients with age-related macular degeneration than in the control group. Macular pigment optical density may be a marker for the development of age-related macular degeneration in the future in the first-degree relatives of age-related macular degeneration patients. Further prospective studies with a larger number of participants will be needed to confirm our results moreover, to clarify its benefit as an early diagnostic biomarker.
UNASSIGNED: One hundred and twenty-eight healthy subjects who were first-degree relatives of age-related macular degeneration patients were included in the study (Group 1). As the control group, 74 healthy subjects were included in the study (Group 2). The right eyes of all cases were included in the study. Macular pigment optical density was measured with a commercially available device (MPSII®, Elektron Technology, Switzerland) using technology based on heterochromatic flicker photometry. Central foveal thickness and subfoveal choroidal thickness were measured with spectral-domain optical coherence tomography. Values were compared between the two groups.
UNASSIGNED: There were 54 males and 74 females in Group 1 and 32 males and 42 females in Group 2. The mean ± SD ages of Group 1 and Group 2 were 49.0 ± 7.6 and 41.8 ± 8.6, respectively. Mean ± SD macular pigment optical density values of Group 1 and Group 2 were 0.43 ± 0.09 and 0.47 ± 0.12 (p = 0.048), mean ± SD central foveal thickness were 208 ± 19 and 216 ± 8 µm (p = 0.014), and mean ± SD subfoveal choroidal thickness were 232 ± 29 and 250 ± 21 µm (p = 0.002), respectively.
UNASSIGNED: The macular pigment optical density values were significantly lower in the first-degree relatives of patients with age-related macular degeneration than in the control group. Macular pigment optical density may be a marker for the development of age-related macular degeneration in the future in the first-degree relatives of age-related macular degeneration patients. Further prospective studies with a larger number of participants will be needed to confirm our results moreover, to clarify its benefit as an early diagnostic biomarker.
摘要：
■测量年龄相关性黄斑变性患者一级亲属的黄斑色素光密度，并与健康对照组进行比较。
■本研究包括128名年龄相关性黄斑变性患者一级亲属的健康受试者（第1组）。作为对照组,74名健康受试者被纳入研究(第2组)。所有病例的右眼均纳入研究。使用市售设备（MPSII®，Elektron技术,瑞士)使用基于异色闪烁光度法的技术。中央凹厚度和中央凹脉络膜厚度通过光谱域光学相干断层扫描测量。比较两组的数值。
■第1组有54名男性和74名女性，第2组有32名男性和42名女性。第1组和第2组的平均±SD年龄分别为49.0±7.6和41.8±8.6。第1组和第2组的平均±SD黄斑色素光密度值分别为0.43±0.09和0.47±0.12（p=0.048），平均±SD中央凹厚度为208±19和216±8µm（p=0.014），平均±SD中心凹下脉络膜厚度为232±29和250±21µm（p=0.002），分别。
■年龄相关性黄斑变性患者一级亲属的黄斑色素光密度值明显低于对照组。在年龄相关性黄斑变性患者的一级亲属中，黄斑色素光密度可能是未来年龄相关性黄斑变性发展的标志。此外，还需要对更多参与者进行进一步的前瞻性研究来证实我们的结果，以阐明其作为早期诊断生物标志物的益处。
■本研究包括128名年龄相关性黄斑变性患者一级亲属的健康受试者（第1组）。作为对照组,74名健康受试者被纳入研究(第2组)。所有病例的右眼均纳入研究。使用市售设备（MPSII®，Elektron技术,瑞士)使用基于异色闪烁光度法的技术。中央凹厚度和中央凹脉络膜厚度通过光谱域光学相干断层扫描测量。比较两组的数值。
■第1组有54名男性和74名女性，第2组有32名男性和42名女性。第1组和第2组的平均±SD年龄分别为49.0±7.6和41.8±8.6。第1组和第2组的平均±SD黄斑色素光密度值分别为0.43±0.09和0.47±0.12（p=0.048），平均±SD中央凹厚度为208±19和216±8µm（p=0.014），平均±SD中心凹下脉络膜厚度为232±29和250±21µm（p=0.002），分别。
■年龄相关性黄斑变性患者一级亲属的黄斑色素光密度值明显低于对照组。在年龄相关性黄斑变性患者的一级亲属中，黄斑色素光密度可能是未来年龄相关性黄斑变性发展的标志。此外，还需要对更多参与者进行进一步的前瞻性研究来证实我们的结果，以阐明其作为早期诊断生物标志物的益处。
