PDF(Pubmed)
Abstract：
Altering the diet to treat disease dates to c. 400 BC when starvation was used to reduce seizures in persons with epilepsy. The current diversity of symptomology and mechanisms underlying autism spectrum disorders (ASDs) and a corresponding lack of disorder-specific effective treatments prompts an evaluation of diet as a therapeutic approach to improve symptoms of ASDs. In this review article, we summarize the main findings of nutritional studies in ASDs, with an emphasis on the most common monogenic cause of autism, Fragile X Syndrome (FXS), and the most studied dietary intervention, the ketogenic diet as well as other dietary interventions. We also discuss the gut microbiota in relation to pre- and probiotic therapies and provide insight into future directions that could aid in understanding the mechanism(s) underlying dietary efficacy.
摘要：
改变饮食以治疗疾病日期为c。当饥饿用于减少癫痫患者的癫痫发作时，公元前400年。当前自闭症谱系障碍（ASD）的症状学和机制的多样性以及相应的缺乏针对特定疾病的有效治疗方法，促使人们将饮食评估为改善ASD症状的治疗方法。在这篇评论文章中，我们总结了ASD营养研究的主要发现，强调自闭症最常见的单基因病因，脆性X综合征（FXS），研究最多的饮食干预，生酮饮食以及其他饮食干预措施。我们还讨论了与前和益生菌疗法相关的肠道微生物群，并提供了对未来方向的见解，这些方向可以帮助理解饮食功效的潜在机制。
