PDF(Pubmed)
Abstract：
BACKGROUND: Management of a bladder tumor during pregnancy is an uncommon clinical situation. Leiomyosarcoma of the urinary bladder is a rare histological type of bladder tumor and a rare secondary cancer in survivors of retinoblastoma (RB). However, there has been no report of RB-associated bladder leiomyosarcoma during pregnancy.
METHODS: A 37-year-old pregnant woman with a medical history of RB in infancy presented with gross hematuria at the 17th week of gestation. Cystoscopy revealed a 40-mm papillary tumor on the left lateral wall of the urinary bladder. At the 25th week of gestation, she underwent transurethral resection of the bladder tumor, and the pathological diagnosis was bladder leiomyosarcoma with loss of RB1 expression. At the 31st week of gestation, she gave birth by caesarean section. One month after the delivery (to allow for involution of the uterus), she underwent partial cystectomy, and the specimen contained no residual leiomyosarcoma tissue.
CONCLUSIONS: We have reported a case of RB-associated bladder leiomyosarcoma that was successfully treated during and after pregnancy.
METHODS: A 37-year-old pregnant woman with a medical history of RB in infancy presented with gross hematuria at the 17th week of gestation. Cystoscopy revealed a 40-mm papillary tumor on the left lateral wall of the urinary bladder. At the 25th week of gestation, she underwent transurethral resection of the bladder tumor, and the pathological diagnosis was bladder leiomyosarcoma with loss of RB1 expression. At the 31st week of gestation, she gave birth by caesarean section. One month after the delivery (to allow for involution of the uterus), she underwent partial cystectomy, and the specimen contained no residual leiomyosarcoma tissue.
CONCLUSIONS: We have reported a case of RB-associated bladder leiomyosarcoma that was successfully treated during and after pregnancy.
摘要：
背景：妊娠期间膀胱肿瘤的治疗是一种罕见的临床情况。膀胱平滑肌肉瘤是一种罕见的组织学类型的膀胱肿瘤，也是视网膜母细胞瘤（RB）幸存者中罕见的继发性癌症。然而,没有妊娠期间RB相关膀胱平滑肌肉瘤的报道.
方法：一名37岁孕妇，在婴儿期有RB病史，在妊娠第17周时出现肉眼血尿。膀胱镜检查显示膀胱左侧壁有一个40毫米的乳头状肿瘤。在妊娠的第25周,她接受了经尿道膀胱肿瘤切除术,病理诊断为膀胱平滑肌肉瘤，RB1表达缺失。在妊娠的第31周，她剖腹产。分娩后一个月（允许子宫复旧），她接受了膀胱部分切除术,标本中没有残留的平滑肌肉瘤组织。
结论：我们报道了一例RB相关的膀胱平滑肌肉瘤，在妊娠期间和之后均得到了成功治疗。
方法：一名37岁孕妇，在婴儿期有RB病史，在妊娠第17周时出现肉眼血尿。膀胱镜检查显示膀胱左侧壁有一个40毫米的乳头状肿瘤。在妊娠的第25周,她接受了经尿道膀胱肿瘤切除术,病理诊断为膀胱平滑肌肉瘤，RB1表达缺失。在妊娠的第31周，她剖腹产。分娩后一个月（允许子宫复旧），她接受了膀胱部分切除术,标本中没有残留的平滑肌肉瘤组织。
结论：我们报道了一例RB相关的膀胱平滑肌肉瘤，在妊娠期间和之后均得到了成功治疗。
