PDF(Pubmed)
Abstract：
Current evidence on de novo metastatic breast cancer is based on data from women. This Swedish population-based cohort study compared the incidence over time and prognosis of de novo metastatic breast cancer between sexes using data from the Swedish National Quality Register for Breast Cancer. Joinpoint regression analysis was used to compare incidence trends in all stages (104 733 women, 648 men) and multivariate Cox regression analysis to investigate potential sex disparities in de novo metastatic breast cancer prognosis (6005 women, 41 men). For both sexes, increased trends were evident for cancer stages I and II, with a stabilizing trend at the later years for women, while stage III incidence remained stable. An increased trend for de novo metastatic breast cancer in women, and to a lesser extent in men, was observed. No difference in de novo metastatic breast cancer overall survival between sexes was observed (hazard ratio = 1.24; 95% confidence interval = 0.85 to 1.81). The comparable features in terms of incidence and prognosis of de novo metastatic breast cancer between sexes imply similarities, supporting the adoption of common treatment strategies.
摘要：
关于从头转移性乳腺癌的当前证据是基于来自女性的数据。这项基于瑞典人群的队列研究使用瑞典国家乳腺癌质量登记册的数据，比较了性别之间从头转移性乳腺癌的发病率和预后。Joinpoint回归分析用于比较所有阶段的发病率趋势（104733名女性，648名男性）和多变量Cox回归分析，以调查新发转移性乳腺癌预后的潜在性别差异（6005名女性，41名男子）。对两性来说，癌症I期和II期的增加趋势明显，随着女性晚年的稳定趋势，而III期发病率保持稳定。女性从头转移性乳腺癌的增加趋势，在较小程度上，在男性中，被观察到。性别间的从头转移性乳腺癌总生存期没有差异（风险比=1.24；95％置信区间=0.85至1.81）。性别间新转移性乳腺癌的发病率和预后方面的可比特征暗示了相似性，支持采用共同的治疗策略。
