Abstract：
Most people with major depressive episodes meet the criteria for the anxious distress (AD) specifier defined by DSM-5 as the presence of symptoms such as feelings of tension, restlessness, difficulty concentrating, and fear that something awful may happen. This cross-sectional study was aimed at identifying clinical correlates of AD in people with unipolar or bipolar depression.
Inpatients with a current major depressive episode were included. Data on socio-demographic and clinical variables were collected. The SCID-5 was used to diagnose depressive episodes and relevant specifiers. The Montgomery-Åsberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) were used to assess the severity of depressive and manic (mixed) symptoms, respectively. Multiple logistic regression analyses were carried out to identify clinical correlates of AD.
We included 206 people (mean age: 48.4 ± 18.6 yrs.; males: 38.8%) admitted for a major depressive episode (155 with major depressive disorder and 51 with bipolar disorder). Around two-thirds of the sample (N = 137; 66.5%) had AD. Multiple logistic regression models showed that AD was associated with mixed features, higher YMRS scores, psychotic features, and a diagnosis of major depressive disorder (p < 0.05).
Despite some limitations, including the cross-sectional design and the inpatient setting, our study shows that AD is likely to be associated with mixed and psychotic features, as well as with unipolar depression. The identification of these clinical domains may help clinicians to better contextualize AD in the context of major depressive episodes.
Inpatients with a current major depressive episode were included. Data on socio-demographic and clinical variables were collected. The SCID-5 was used to diagnose depressive episodes and relevant specifiers. The Montgomery-Åsberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) were used to assess the severity of depressive and manic (mixed) symptoms, respectively. Multiple logistic regression analyses were carried out to identify clinical correlates of AD.
We included 206 people (mean age: 48.4 ± 18.6 yrs.; males: 38.8%) admitted for a major depressive episode (155 with major depressive disorder and 51 with bipolar disorder). Around two-thirds of the sample (N = 137; 66.5%) had AD. Multiple logistic regression models showed that AD was associated with mixed features, higher YMRS scores, psychotic features, and a diagnosis of major depressive disorder (p < 0.05).
Despite some limitations, including the cross-sectional design and the inpatient setting, our study shows that AD is likely to be associated with mixed and psychotic features, as well as with unipolar depression. The identification of these clinical domains may help clinicians to better contextualize AD in the context of major depressive episodes.
摘要：
目标：大多数患有重度抑郁发作的人符合DSM-5定义的焦虑困扰（AD）说明符的标准，例如存在紧张的感觉，躁动,难以集中注意力,害怕可怕的事情发生.这项横断面研究旨在确定单相或双相抑郁症患者AD的临床相关性。
方法：纳入目前患有重度抑郁发作的住院患者。收集社会人口统计学和临床变量的数据。SCID-5用于诊断抑郁发作和相关说明符。蒙哥马利-奥斯贝格抑郁量表（MADRS）和青年躁狂量表（YMRS）用于评估抑郁和躁狂（混合）症状的严重程度。分别。进行多逻辑回归分析以确定AD的临床相关性。
结果：我们包括206人（平均年龄：48.4±18.6岁。；男性：38.8％）因重度抑郁发作而入院（155例患有重度抑郁障碍，51例患有双相情感障碍）。大约三分之二的样品(N=137;66.5%)患有AD。多元logistic回归模型显示AD与混合特征相关,更高的YMRS分数，精神病特征，和严重抑郁障碍的诊断（p<0.05）。
结论：尽管有一些限制，包括横断面设计和住院设置，我们的研究表明，AD可能与混合和精神病特征有关，以及单极抑郁症。这些临床领域的识别可能有助于临床医生在重度抑郁发作的背景下更好地了解AD。
方法：纳入目前患有重度抑郁发作的住院患者。收集社会人口统计学和临床变量的数据。SCID-5用于诊断抑郁发作和相关说明符。蒙哥马利-奥斯贝格抑郁量表（MADRS）和青年躁狂量表（YMRS）用于评估抑郁和躁狂（混合）症状的严重程度。分别。进行多逻辑回归分析以确定AD的临床相关性。
结果：我们包括206人（平均年龄：48.4±18.6岁。；男性：38.8％）因重度抑郁发作而入院（155例患有重度抑郁障碍，51例患有双相情感障碍）。大约三分之二的样品(N=137;66.5%)患有AD。多元logistic回归模型显示AD与混合特征相关,更高的YMRS分数，精神病特征，和严重抑郁障碍的诊断（p<0.05）。
结论：尽管有一些限制，包括横断面设计和住院设置，我们的研究表明，AD可能与混合和精神病特征有关，以及单极抑郁症。这些临床领域的识别可能有助于临床医生在重度抑郁发作的背景下更好地了解AD。
