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Abstract：
This study was designed to investigate the differences in skeletal-muscle atrophy between patients with stable chronic obstructive pulmonary disease (COPD) and healthy controls; associated factors were also considered. The study comprised selected residents of communities near the First Affiliated Hospital of Soochow University in Suzhou City, East China.
Included in this study were 123 COPD patients and 60 controls. All patients completed spirometry as well as examinations to determine their functional exercise capacity, body composition, and handgrip strength (HGS).
COPD patients had less fat-free mass (FFM), a lower FFM index (FFMI), and a lower 6-min walking distance (6MWD) compared with controls (P = 0.007, P = 0.020, and P < 0.001, respectively) (FFMI: 17.59 ± 1.83 vs 18.34 ± 1.64). The HGS of these patients was also lower compared with that of controls (32.88 ± 7.84 vs 35.48 ± 7.42), and HGS tended toward statistical significance (P = 0.064, respectively). In multivariate analysis, age (β = -0.107, P < 0.001), gender (β = 0.212, P < 0.001), body mass index (BMI) (β = 0.462, P < 0.001), FEV1% (β = 0.108, P = 0.009), and calf circumference (CC) (β = 0.457, P < 0.001) were significantly associated with FFMI.
Impaired skeletal muscle mass was more common in COPD patients than in controls. Multiple regression analysis showed that CC may be used to detect the degree of impairment, particularly by health-care providers working outside of the hospital.
Included in this study were 123 COPD patients and 60 controls. All patients completed spirometry as well as examinations to determine their functional exercise capacity, body composition, and handgrip strength (HGS).
COPD patients had less fat-free mass (FFM), a lower FFM index (FFMI), and a lower 6-min walking distance (6MWD) compared with controls (P = 0.007, P = 0.020, and P < 0.001, respectively) (FFMI: 17.59 ± 1.83 vs 18.34 ± 1.64). The HGS of these patients was also lower compared with that of controls (32.88 ± 7.84 vs 35.48 ± 7.42), and HGS tended toward statistical significance (P = 0.064, respectively). In multivariate analysis, age (β = -0.107, P < 0.001), gender (β = 0.212, P < 0.001), body mass index (BMI) (β = 0.462, P < 0.001), FEV1% (β = 0.108, P = 0.009), and calf circumference (CC) (β = 0.457, P < 0.001) were significantly associated with FFMI.
Impaired skeletal muscle mass was more common in COPD patients than in controls. Multiple regression analysis showed that CC may be used to detect the degree of impairment, particularly by health-care providers working outside of the hospital.
摘要：
■本研究旨在调查慢性阻塞性肺疾病（COPD）稳定期患者和健康对照组之间骨骼肌萎缩的差异；还考虑了相关因素。这项研究包括苏州市苏州大学附属第一医院附近社区的部分居民，华东地区。
■这项研究包括123名COPD患者和60名对照。所有患者都完成了肺活量测定和检查，以确定他们的功能运动能力，身体成分,和手握强度（HGS）。
■COPD患者的无脂质量（FFM）较少，较低的FFM指数(FFMI)，与对照组相比，6分钟步行距离（6MWD）较低（分别为P=0.007，P=0.020和P<0.001）（FFMI：17.59±1.83vs18.34±1.64）。与对照组相比，这些患者的HGS也较低（32.88±7.84vs35.48±7.42），和HGS具有统计学意义（分别为P=0.064）。在多变量分析中，年龄（β=-0.107，P<0.001），性别（β=0.212，P<0.001），体重指数(BMI)(β=0.462,P<0.001),FEV1%(β=0.108,P=0.009),和小腿围（CC）（β=0.457，P<0.001）与FFMI显着相关。
与对照组相比，COPD患者的骨骼肌质量受损更为常见。多元回归分析表明，CC可用于检测损伤程度，特别是在医院外工作的医疗保健提供者。
■这项研究包括123名COPD患者和60名对照。所有患者都完成了肺活量测定和检查，以确定他们的功能运动能力，身体成分,和手握强度（HGS）。
■COPD患者的无脂质量（FFM）较少，较低的FFM指数(FFMI)，与对照组相比，6分钟步行距离（6MWD）较低（分别为P=0.007，P=0.020和P<0.001）（FFMI：17.59±1.83vs18.34±1.64）。与对照组相比，这些患者的HGS也较低（32.88±7.84vs35.48±7.42），和HGS具有统计学意义（分别为P=0.064）。在多变量分析中，年龄（β=-0.107，P<0.001），性别（β=0.212，P<0.001），体重指数(BMI)(β=0.462,P<0.001),FEV1%(β=0.108,P=0.009),和小腿围（CC）（β=0.457，P<0.001）与FFMI显着相关。
与对照组相比，COPD患者的骨骼肌质量受损更为常见。多元回归分析表明，CC可用于检测损伤程度，特别是在医院外工作的医疗保健提供者。
