Abstract：
BACKGROUND: Herbal medicines have been used for the preparation of numerous pharmaceutical products for the treatment of human disorders. Plant-derived products have been used in medicine, nutraceuticals, perfumery, beverages, and cosmetics industries for different purposes. Herbal medicines are mainly derived from different parts of plant materials. Phellodendron bark has been widely known as one of the fundamental herbs of traditional Chinese medicine. Phellodendron bark contains phellodendrine as a main active phytochemical. Phellodendrine ((7S,13aS)-3,10-dimethoxy-7-methyl-6,8,13,13atetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7- ium-2,11-diol), is a quaternary ammonium alkaloid.
METHODS: This present study aimed to investigate the biological potential and therapeutic effectiveness of phellodendrine in medicine through scientific data analysis of different research works on phellodendrine. The therapeutic value of phellodendrine was analyzed in the present work through scientific data available in Google, Google Scholar, ScienceDirect, and PubMed. All the scientific data on phellodendrine were collected from these databases using the terms herbal drugs and phellodendrine. Pharmacological and analytical data of phellodendrine were analyzed in the present work in order to know the medicinal importance of phellodendrine.
RESULTS: Scientific data analysis of phellodendrine in the present work signified the biological importance of phellodendrine in medicine. Phellodendrine has numerous beneficial aspects in medicine due to its potential benefits in ulcerative colitis, inflammation, pancreatic cancer, nephritis, immune response, acetylcholinesterase activity, psoriasis, arthritis, atopic dermatitis, and oxidative stress. However, it also has significant effects on eicosanoid generation, neuraminidase-1, inflammasome generation, cytochrome p450, taste receptors, and hepatic gluconeogenesis. Furthermore, scientific data has indicated the presence of phellodendrine in different natural sources, including Phellodendri cortex. Analytical data on phellodendrines has signified their importance in the isolation and separation of pure phytochemicals in medicine. Pharmacokinetic parameters have highlighted the tissue distribution of phellodendrine in different tissue of human beings and higher animals.
CONCLUSIONS: In the present work, scientific data analysis has indicated the biological importance, pharmacological activities, and analytical aspects of phellodendrine in medicine.
METHODS: This present study aimed to investigate the biological potential and therapeutic effectiveness of phellodendrine in medicine through scientific data analysis of different research works on phellodendrine. The therapeutic value of phellodendrine was analyzed in the present work through scientific data available in Google, Google Scholar, ScienceDirect, and PubMed. All the scientific data on phellodendrine were collected from these databases using the terms herbal drugs and phellodendrine. Pharmacological and analytical data of phellodendrine were analyzed in the present work in order to know the medicinal importance of phellodendrine.
RESULTS: Scientific data analysis of phellodendrine in the present work signified the biological importance of phellodendrine in medicine. Phellodendrine has numerous beneficial aspects in medicine due to its potential benefits in ulcerative colitis, inflammation, pancreatic cancer, nephritis, immune response, acetylcholinesterase activity, psoriasis, arthritis, atopic dermatitis, and oxidative stress. However, it also has significant effects on eicosanoid generation, neuraminidase-1, inflammasome generation, cytochrome p450, taste receptors, and hepatic gluconeogenesis. Furthermore, scientific data has indicated the presence of phellodendrine in different natural sources, including Phellodendri cortex. Analytical data on phellodendrines has signified their importance in the isolation and separation of pure phytochemicals in medicine. Pharmacokinetic parameters have highlighted the tissue distribution of phellodendrine in different tissue of human beings and higher animals.
CONCLUSIONS: In the present work, scientific data analysis has indicated the biological importance, pharmacological activities, and analytical aspects of phellodendrine in medicine.
摘要：
背景:草药已经用于制备用于治疗人类疾病的许多药物产品。植物衍生产品已被用于医药,营养食品，香水,饮料,和不同用途的化妆品行业。草药主要来自植物材料的不同部位。黄柏树皮被广泛认为是中药的基本草药之一。黄柏树皮中含有黄柏碱作为主要的活性植物化学物质。黄柏((7S,13aS)-3,10-二甲氧基-7-甲基-6,8,13,13-四氢-5H-异喹啉基[2,1-b]异喹啉-7-鎓-2,11-二醇)，是季铵生物碱。
方法：本研究旨在通过对黄柏碱不同研究工作的科学数据分析，探讨黄柏碱在医学上的生物学潜力和治疗效果。通过Google提供的科学数据，在当前工作中分析了黄柏碱的治疗价值，谷歌学者，ScienceDirect,和PubMed。关于黄柏碱的所有科学数据都是从这些数据库中使用术语草药和黄柏碱收集的。为了了解黄柏碱的药用重要性，在本工作中分析了黄柏碱的药理和分析数据。
结果：本工作中黄柏碱的科学数据分析表明黄柏碱在医学中的生物学重要性。由于黄柏在溃疡性结肠炎中的潜在益处，黄柏在医学上有许多有益的方面，炎症,胰腺癌,肾炎,免疫反应，乙酰胆碱酯酶活性，牛皮癣,关节炎,特应性皮炎,和氧化应激。然而,它对二十烷酸的产生也有显著的影响，神经氨酸酶-1，炎性体生成，细胞色素p450味觉受体,和肝糖异生。此外，科学数据表明黄柏碱存在于不同的天然来源中，包括黄柏皮质.黄柏属植物的分析数据表明了它们在医学中分离和分离纯植物化学物质中的重要性。药代动力学参数突出了黄柏碱在人类和高等动物不同组织中的组织分布。
结论：在目前的工作中，科学数据分析表明了生物学的重要性，药理活性，以及黄柏碱在医学中的分析方面。
方法：本研究旨在通过对黄柏碱不同研究工作的科学数据分析，探讨黄柏碱在医学上的生物学潜力和治疗效果。通过Google提供的科学数据，在当前工作中分析了黄柏碱的治疗价值，谷歌学者，ScienceDirect,和PubMed。关于黄柏碱的所有科学数据都是从这些数据库中使用术语草药和黄柏碱收集的。为了了解黄柏碱的药用重要性，在本工作中分析了黄柏碱的药理和分析数据。
结果：本工作中黄柏碱的科学数据分析表明黄柏碱在医学中的生物学重要性。由于黄柏在溃疡性结肠炎中的潜在益处，黄柏在医学上有许多有益的方面，炎症,胰腺癌,肾炎,免疫反应，乙酰胆碱酯酶活性，牛皮癣,关节炎,特应性皮炎,和氧化应激。然而,它对二十烷酸的产生也有显著的影响，神经氨酸酶-1，炎性体生成，细胞色素p450味觉受体,和肝糖异生。此外，科学数据表明黄柏碱存在于不同的天然来源中，包括黄柏皮质.黄柏属植物的分析数据表明了它们在医学中分离和分离纯植物化学物质中的重要性。药代动力学参数突出了黄柏碱在人类和高等动物不同组织中的组织分布。
结论：在目前的工作中，科学数据分析表明了生物学的重要性，药理活性，以及黄柏碱在医学中的分析方面。
