PDF(Pubmed)
Abstract：
UNASSIGNED: Duration of untreated psychosis (DUP) is an important modifiable factor affecting schizophrenia outcomes. A dearth of research in India on untreated versus treated schizophrenia warrants further research.
UNASSIGNED: This was a longitudinal study in a tertiary hospital over 2 years. Inpatients diagnosed with schizophrenia (N = 116), aged 18-45, were divided into untreated and treated groups. Diagnostic confirmation, severity assessment, and clinical outcome were done using ICD-10 criteria, Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression (CGI) scale. Follow-up was done at 12 and 24 weeks. DUP was measured, and its association with the outcome was assessed.
UNASSIGNED: Final analysis included 100 patients, 50 each of previously untreated and treated. Untreated patients had lower age and duration of illness (DOI), but higher DUP (p < .001). Treated patients showed much improvement on CGI-I at 12 weeks (p = .029), with no difference at 24 weeks. PANSS severity comparison showed no difference, and both groups followed a declining trend. In untreated patients, age of onset (AoO) was negatively correlated with severity (except general symptoms at baseline) at all follow-ups (\'r\' range = -0.32 to -0.49, p < .05), while DOI showed a positive correlation with negative and general symptoms at 12 weeks (r ~ 0.3, p < .05). Treated patients showed inconsistent and lower negative correlation between AoO and PANSS, with no correlation between severity and DOI. The mean sample DUP was 17.9 ± 31.6 weeks; it negatively correlated with education (r = -0.25, p = .01) and positively with PANSS severity (\'r\' range = 0.22 to 0.30, p < .05) at all follow-ups, especially negative symptoms. Patients with no or minimal improvement on CGI at 24 weeks had higher DUP (Quade\'s ANOVA F[1,98] = 6.24, p = .014).
UNASSIGNED: Illness variables in untreated schizophrenia affect severity, which has delayed improvement than treated schizophrenia. Higher DUP is associated with negative symptoms of schizophrenia.
UNASSIGNED: This was a longitudinal study in a tertiary hospital over 2 years. Inpatients diagnosed with schizophrenia (N = 116), aged 18-45, were divided into untreated and treated groups. Diagnostic confirmation, severity assessment, and clinical outcome were done using ICD-10 criteria, Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression (CGI) scale. Follow-up was done at 12 and 24 weeks. DUP was measured, and its association with the outcome was assessed.
UNASSIGNED: Final analysis included 100 patients, 50 each of previously untreated and treated. Untreated patients had lower age and duration of illness (DOI), but higher DUP (p < .001). Treated patients showed much improvement on CGI-I at 12 weeks (p = .029), with no difference at 24 weeks. PANSS severity comparison showed no difference, and both groups followed a declining trend. In untreated patients, age of onset (AoO) was negatively correlated with severity (except general symptoms at baseline) at all follow-ups (\'r\' range = -0.32 to -0.49, p < .05), while DOI showed a positive correlation with negative and general symptoms at 12 weeks (r ~ 0.3, p < .05). Treated patients showed inconsistent and lower negative correlation between AoO and PANSS, with no correlation between severity and DOI. The mean sample DUP was 17.9 ± 31.6 weeks; it negatively correlated with education (r = -0.25, p = .01) and positively with PANSS severity (\'r\' range = 0.22 to 0.30, p < .05) at all follow-ups, especially negative symptoms. Patients with no or minimal improvement on CGI at 24 weeks had higher DUP (Quade\'s ANOVA F[1,98] = 6.24, p = .014).
UNASSIGNED: Illness variables in untreated schizophrenia affect severity, which has delayed improvement than treated schizophrenia. Higher DUP is associated with negative symptoms of schizophrenia.
摘要：
■未经治疗的精神病（DUP）的持续时间是影响精神分裂症结局的重要可改变因素。印度缺乏关于未经治疗的精神分裂症与治疗精神分裂症的研究，值得进一步研究。
■这是一项在三级医院进行的为期2年的纵向研究。住院患者诊断为精神分裂症（N=116），年龄18-45岁，分为未治疗组和治疗组。诊断确认,严重性评估，和临床结果使用ICD-10标准，阳性和阴性综合征量表（PANSS），和临床总体印象(CGI)量表。在12周和24周进行随访。DUP被测量，并评估其与结果的关联。
■最终分析包括100名患者，先前未处理和处理的各50个。未经治疗的患者年龄和病程（DOI）较低，但DUP更高（p<.001）。接受治疗的患者在12周时显示CGI-I有很大改善（p=0.029），在24周没有区别。PANSS严重程度比较显示无差异，这两个群体都有下降的趋势。在未经治疗的患者中，在所有随访中，发病年龄（AoO）与严重程度（基线时的一般症状除外）呈负相关（\'r\'范围=-0.32至-0.49，p<0.05），12周时DOI与阴性症状和一般症状呈正相关(r~0.3,p<0.05)。接受治疗的患者AoO和PANSS之间的负相关不一致且较低，严重程度和DOI之间没有相关性。平均样本DUP为17.9±31.6周；在所有随访中，它与教育程度呈负相关（r=-0.25，p=0.01），与PANSS严重程度呈正相关（\'r\'范围=0.22至0.30，p<.05），尤其是阴性症状。在24周时CGI无改善或改善最小的患者具有较高的DUP（Quade的ANOVAF[1,98]=6.24，p=.014）。
■未经治疗的精神分裂症的疾病变量会影响严重程度，比治疗精神分裂症延迟了改善。较高的DUP与精神分裂症的阴性症状有关。
■这是一项在三级医院进行的为期2年的纵向研究。住院患者诊断为精神分裂症（N=116），年龄18-45岁，分为未治疗组和治疗组。诊断确认,严重性评估，和临床结果使用ICD-10标准，阳性和阴性综合征量表（PANSS），和临床总体印象(CGI)量表。在12周和24周进行随访。DUP被测量，并评估其与结果的关联。
■最终分析包括100名患者，先前未处理和处理的各50个。未经治疗的患者年龄和病程（DOI）较低，但DUP更高（p<.001）。接受治疗的患者在12周时显示CGI-I有很大改善（p=0.029），在24周没有区别。PANSS严重程度比较显示无差异，这两个群体都有下降的趋势。在未经治疗的患者中，在所有随访中，发病年龄（AoO）与严重程度（基线时的一般症状除外）呈负相关（\'r\'范围=-0.32至-0.49，p<0.05），12周时DOI与阴性症状和一般症状呈正相关(r~0.3,p<0.05)。接受治疗的患者AoO和PANSS之间的负相关不一致且较低，严重程度和DOI之间没有相关性。平均样本DUP为17.9±31.6周；在所有随访中，它与教育程度呈负相关（r=-0.25，p=0.01），与PANSS严重程度呈正相关（\'r\'范围=0.22至0.30，p<.05），尤其是阴性症状。在24周时CGI无改善或改善最小的患者具有较高的DUP（Quade的ANOVAF[1,98]=6.24，p=.014）。
■未经治疗的精神分裂症的疾病变量会影响严重程度，比治疗精神分裂症延迟了改善。较高的DUP与精神分裂症的阴性症状有关。
