PDF(Pubmed)
Abstract：
Urological tumors, such as prostate cancer, renal cell carcinoma, and bladder cancer, have shown a significant rise in prevalence in recent years and account for a significant proportion of malignant tumors. It has been established that metastasis to distant organs caused by urological tumors is the main cause of death, although the mechanisms underlying metastasis have not been fully elucidated. The fibronectin receptor integrin α5β1 reportedly plays an important role in distant metastasis and is closely related to tumor development. It is widely thought to be an important cancer mediator by interacting with different ligands, mediating tumor adhesion, invasion, and migration, and leading to immune escape. In this paper, we expound on the relationship and regulatory mechanisms of integrin α5β1 in these three cancers. In addition, the clinical applications of integrin α5β1 in these cancers, especially against treatment resistance, are discussed. Last but not least, the possibility of integrin α5β1 as a potential target for treatment is examined, with new ideas for future research being proposed.
摘要：
泌尿系肿瘤,比如前列腺癌，肾细胞癌，膀胱癌，近年来患病率显着上升，并占恶性肿瘤的很大比例。已经确定由泌尿系肿瘤引起的远处器官转移是死亡的主要原因，尽管转移的潜在机制尚未完全阐明。纤连蛋白受体整合素α5β1在远处转移中起重要作用,与肿瘤的发生发展密切相关。它被广泛认为是一种重要的癌症介质，通过与不同的配体相互作用，介导肿瘤粘附，入侵,和移民,导致免疫逃逸。在本文中,本文就整合素α5β1在这三种肿瘤中的相互关系及调控机制进行了阐述。此外,整合素α5β1在这些癌症中的临床应用，特别是对抗治疗抵抗，正在讨论。最后但并非最不重要的,研究了整合素α5β1作为潜在治疗靶点的可能性，提出了未来研究的新思路。
