Abstract：
Coenzyme A (CoA) serves as a vital cofactor in numerous enzymatic reactions involved in energy production, lipid metabolism, and synthesis of essential molecules. Dysregulation of CoA-dependent metabolic pathways can contribute to chronic diseases, such as inflammatory diseases, obesity, diabetes, cancer, and cardiovascular disorders. Additionally, CoA influences immune cell activation by modulating the metabolism of these cells, thereby affecting their proliferation, differentiation, and effector functions. Targeting CoA metabolism presents a promising avenue for therapeutic intervention, as it can potentially restore metabolic balance, mitigate chronic inflammation, and enhance immune cell function. This might ultimately improve the management and outcomes for these diseases. This review will more specifically focus on the contribution of pathways regulating the availability of the CoA precursor Vitamin B5/pantothenate in vivo and modulating the development of Th17-mediated inflammation, CD8-dependent anti-tumor immunity but also tissue repair processes in chronic inflammatory or degenerative diseases.
摘要：
辅酶A在涉及能量生产的许多酶促反应中充当重要的辅因子。脂质代谢，和必需分子的合成。CoA依赖性代谢途径的失调可导致慢性疾病，如炎症性疾病。肥胖，糖尿病,癌症,和心血管疾病。此外,CoA通过调节这些细胞的代谢来影响免疫细胞的活化，从而影响它们的扩散，分化,和效应器功能。靶向CoA代谢为治疗干预提供了一个有希望的途径，因为它有可能恢复代谢平衡，缓解慢性炎症，增强免疫细胞功能。这可能最终改善这些疾病的管理和结果。这篇综述将更具体地关注调节辅酶A前体维生素B5/泛酸在体内的可用性和调节Th17介导的炎症发展的途径的贡献，CD8依赖性抗肿瘤免疫以及慢性炎症或退行性疾病中的组织修复过程。本文受版权保护。保留所有权利。
