PDF(Pubmed)
Abstract：
Here we examine the effects of ambient red light on lens-induced myopia and diffuser-induced myopia in tree shrews, small diurnal mammals closely related to primates. Starting at 24 days of visual experience (DVE), seventeen tree shrews were reared in red light (624 ± 10 or 634 ± 10 nm, 527-749 human lux) for 12-14 days wearing either a -5D lens (RL-5D, n = 5) or a diffuser (RLFD, n = 5) monocularly, or without visual restriction (RL-Control, n = 7). Refractive errors and ocular dimensions were compared to those obtained from tree shrews raised in broad-spectrum white light (WL-5D, n = 5; WLFD, n = 10; WL Control, n = 7). The RL-5D tree shrews developed less myopia in their lens-treated eyes than WL-5D tree shrews at the end of the experiment (-1.1 ± 0.9D vs. -3.8 ± 0.3D, p = 0.007). The diffuser-treated eyes of the RLFD tree shrews were near-emmetropic (-0.3 ± 0.6D, vs. -5.4 ± 0.7D in the WLFD group). Red light induced hyperopia in control animals (RL-vs. WL-Control, +3.0 ± 0.7 vs. +1.0 ± 0.2D, p = 0.02), the no-lens eyes of the RL-5D animals, and the no-diffuser eyes of the RLFD animals (+2.5 ± 0.5D and +2.3 ± 0.3D, respectively). The refractive alterations were consistent with the alterations in vitreous chamber depth. The lens-induced myopia developed in red light suggests that a non-chromatic cue could signal defocus to a less accurate extent, although it could also be a result of \"form-deprivation\" caused by defocus blur. As with previous studies in rhesus monkeys, the ability of red light to promote hyperopia appears to correlate with its ability to retard lens-induced myopia and form-deprivation myopia, the latter of which might be related to non-visual ocular mechanisms.
摘要：
在这里，我们研究了环境红光对晶状体诱导的近视和漫射器诱导的近视的影响。与灵长类动物密切相关的小型昼夜哺乳动物。从24天的视觉体验（DVE）开始，在红光(624±10或634±10纳米，527-749人类勒克斯）佩戴-5D镜头（RL-5D，n=5)或扩散器(RLFD,n=5)单眼，或没有视觉限制(RL-Control,n=7)。将屈光误差和眼睛尺寸与从广谱白光中升起的树sh获得的屈光误差和眼睛尺寸进行了比较（WL-5D，n=5;WLFD,n=10；WL控制，n=7)。在实验结束时，与WL-5D树sh相比，RL-5D树sh在晶状体处理的眼睛中近视程度较低（-1.1±0.9Dvs.-3.8±0.3D,p=0.007)。RLFD树sh的扩散器处理的眼睛接近正视（-0.3±0.6D，vs.WLFD组的-5.4±0.7D）。对照动物中红光诱导的远视（RL-vs.WL控制，+3.0±0.7vs.+1.0±0.2D,p=0.02),RL-5D动物的无晶状体眼睛，以及RLFD动物的无扩散器眼睛（+2.5±0.5D和+2.3±0.3D，分别)。屈光改变与玻璃体腔深度的改变一致。在红光下发展的晶状体引起的近视表明，非彩色提示可能会发出散焦信号，尽管这也可能是由散焦模糊引起的“形式剥夺”的结果。和以前对恒河猴的研究一样，红光促进远视的能力似乎与其延缓晶状体诱导的近视和形觉剥夺性近视的能力相关，后者可能与非视觉视觉机制有关。
