Abstract：
We aimed to investigate whether maternal serum kisspeptin levels are associated with late-onset FGR and contribute to adverse perinatal outcomes.
In this case-control study, a total of 90 pregnant women admitted to the perinatology clinic were enrolled. Forty-five of them were diagnosed with FGR and 45 women with healthy pregnancies formed the control group. Maternal serum levels of kisspeptin 1 were compared.
Median kisspeptin1 serum levels were higher in the group of patients with FGR according to gestational age than in the control group [79.4(3.9-230.2) pg/mL vs. 39.8(0.4-188.3) pg/mL; p = 0.001]. The optimal cut-off value for kisspeptin1 was 30.32 pg/mL, with a positive predictive value of 64.6% (95% CI; 0.54-0.86), negative predictive value of 87.5% (95% CI; 0.44-0.72), positive likelihood ratio 1.75 (95% CI; 1.31-2.32), negative likelihood ratio 0.14 (95% CI; 0.04-0.44).
Kisspeptin1 differed significantly in late-onset FGR compared with the control group. This difference from the control group can be used to estimate late-onset FGR.
In this case-control study, a total of 90 pregnant women admitted to the perinatology clinic were enrolled. Forty-five of them were diagnosed with FGR and 45 women with healthy pregnancies formed the control group. Maternal serum levels of kisspeptin 1 were compared.
Median kisspeptin1 serum levels were higher in the group of patients with FGR according to gestational age than in the control group [79.4(3.9-230.2) pg/mL vs. 39.8(0.4-188.3) pg/mL; p = 0.001]. The optimal cut-off value for kisspeptin1 was 30.32 pg/mL, with a positive predictive value of 64.6% (95% CI; 0.54-0.86), negative predictive value of 87.5% (95% CI; 0.44-0.72), positive likelihood ratio 1.75 (95% CI; 1.31-2.32), negative likelihood ratio 0.14 (95% CI; 0.04-0.44).
Kisspeptin1 differed significantly in late-onset FGR compared with the control group. This difference from the control group can be used to estimate late-onset FGR.
摘要：
背景：我们的目的是调查母体血清kisspeptin水平是否与迟发性FGR相关，并导致不良的围产期结局。
方法：在本病例对照研究中，共有90名孕妇被纳入围产期诊所.其中45名被诊断为FGR，45名健康怀孕的妇女组成了对照组。比较了母亲血清中kisspeptin1的水平。
结果：根据胎龄，FGR患者组的kisspeptin1血清中位数水平高于对照组[79.4（3.9-230.2）pg/mLvs.39.8（0.4-188.3）pg/mL；p=0.001]。kisspeptin1的最佳临界值为30.32pg/mL，阳性预测值为64.6%(95%CI；0.54-0.86)，阴性预测值为87.5%（95%CI；0.44-0.72），正似然比1.75（95%CI；1.31-2.32），负似然比0.14（95%CI；0.04-0.44）。
结论：Kisspeptin1在晚发型FGR中与对照组相比有显著差异。与对照组的这种差异可用于估计迟发性FGR。
方法：在本病例对照研究中，共有90名孕妇被纳入围产期诊所.其中45名被诊断为FGR，45名健康怀孕的妇女组成了对照组。比较了母亲血清中kisspeptin1的水平。
结果：根据胎龄，FGR患者组的kisspeptin1血清中位数水平高于对照组[79.4（3.9-230.2）pg/mLvs.39.8（0.4-188.3）pg/mL；p=0.001]。kisspeptin1的最佳临界值为30.32pg/mL，阳性预测值为64.6%(95%CI；0.54-0.86)，阴性预测值为87.5%（95%CI；0.44-0.72），正似然比1.75（95%CI；1.31-2.32），负似然比0.14（95%CI；0.04-0.44）。
结论：Kisspeptin1在晚发型FGR中与对照组相比有显著差异。与对照组的这种差异可用于估计迟发性FGR。
