Abstract：
OBJECTIVE: Juvenile nasopharyngeal angiofibroma (JNA) is a very rare hemorrhagic vascular tumor that predominantly affects adolescent boys. The tumor is relatively large when detected, and the risk of intraoperative bleeding is high. We aimed to examine factors associated with intraoperative blood loss in JNA surgery.
METHODS: Thirteen patients with JNA who underwent surgery at the Jikei University Hospital between 2009 and 2020 were retrospectively reviewed, and factors associated with blood loss were examined by single regression analysis.
RESULTS: The mean age was 20.8 ± 7.7 years. Preoperative angiographic images were evaluated in 9 of the 13 cases. The 6 patients with the largest bleeding volumes, all had residual nutrient vessels from the internal carotid artery (ICA), with an average number of 2.5 vessels. The mean blood loss of patients with residual nutrient vessels from the ICA was 3037 ± 2568 mL. Single regression analysis of bleeding volume against the number of remaining nutrient vessels from the ICA and the total peak contrast density of nutrient vessels (Cmax) standardized by region of interest showed that the coefficient was positive (P < 0.05 for both), confirming a significant correlation between the 2, respectively.
CONCLUSIONS: The amount of bleeding significantly correlated with the number of remaining nutrient vessels from the ICA after preoperative embolization and with the total Cmax/region of interest. The ability to predict the amount of preoperative blood loss using this study will facilitate proposals for external incisions in patients with JNA.
METHODS: Thirteen patients with JNA who underwent surgery at the Jikei University Hospital between 2009 and 2020 were retrospectively reviewed, and factors associated with blood loss were examined by single regression analysis.
RESULTS: The mean age was 20.8 ± 7.7 years. Preoperative angiographic images were evaluated in 9 of the 13 cases. The 6 patients with the largest bleeding volumes, all had residual nutrient vessels from the internal carotid artery (ICA), with an average number of 2.5 vessels. The mean blood loss of patients with residual nutrient vessels from the ICA was 3037 ± 2568 mL. Single regression analysis of bleeding volume against the number of remaining nutrient vessels from the ICA and the total peak contrast density of nutrient vessels (Cmax) standardized by region of interest showed that the coefficient was positive (P < 0.05 for both), confirming a significant correlation between the 2, respectively.
CONCLUSIONS: The amount of bleeding significantly correlated with the number of remaining nutrient vessels from the ICA after preoperative embolization and with the total Cmax/region of interest. The ability to predict the amount of preoperative blood loss using this study will facilitate proposals for external incisions in patients with JNA.
摘要：
目的：青少年鼻咽血管纤维瘤（JNA）是一种非常罕见的出血性血管肿瘤，主要影响青少年男孩。检测到肿瘤相对较大，术中出血的风险很高。我们旨在研究与JNA手术中失血相关的因素。
方法：回顾性分析了2009年至2020年在继经大学医院接受手术治疗的13例JNA患者，并通过单因素回归分析检查与失血相关的因素。
结果：平均年龄为20.8±7.7岁。对13例中的9例术前血管造影图像进行了评估。6例出血量最大的患者都有来自颈内动脉的残余营养血管，平均有2.5艘船。颈内动脉残留营养血管患者的平均失血量为3,037±2,568mL。对颈内动脉剩余营养血管数量和营养血管总峰值对比密度（Cmax）的单因素回归分析显示，该系数均为正（p<0.05），证实了两者之间的显著相关性，分别。
结论：术前栓塞后颈内动脉剩余营养血管的数量和总Cmax/ROI的出血量显著相关。使用这项研究预测术前失血量的能力将有助于为JNA患者提供外部切口的建议。
方法：回顾性分析了2009年至2020年在继经大学医院接受手术治疗的13例JNA患者，并通过单因素回归分析检查与失血相关的因素。
结果：平均年龄为20.8±7.7岁。对13例中的9例术前血管造影图像进行了评估。6例出血量最大的患者都有来自颈内动脉的残余营养血管，平均有2.5艘船。颈内动脉残留营养血管患者的平均失血量为3,037±2,568mL。对颈内动脉剩余营养血管数量和营养血管总峰值对比密度（Cmax）的单因素回归分析显示，该系数均为正（p<0.05），证实了两者之间的显著相关性，分别。
结论：术前栓塞后颈内动脉剩余营养血管的数量和总Cmax/ROI的出血量显著相关。使用这项研究预测术前失血量的能力将有助于为JNA患者提供外部切口的建议。
