Abstract：
Complex regional pain syndrome is a chronic debilitating pain disorder that is difficult to manage, in part due to its heterogeneous clinical presentation and lack of clearly defined pathophysiology. Patients usually require a multidisciplinary approach to treatment, which can entail pharmacotherapy, physical therapy, behavioral therapy, and interventional pain procedures, such as sympathetic nerve blocks, spinal cord stimulation, and dorsal root ganglion stimulation. However, many patients continue to experience pain refractory to these multimodal strategies. Scrambler therapy (ST) is a noninvasive method of neuromodulation that is applied through cutaneous electrodes, and can alleviate chronic neuropathic pain by stimulating C-fibers and replacing endogenous pain signals with synthetic non-nociceptive signals. Although the use of ST has been reported for several types of refractory central and peripheral neuropathic pain, there is a paucity of data regarding the use of ST for complex regional pain syndrome. We present two patients with complex regional pain syndrome of the right lower extremity, who each underwent ST and experienced significant pain relief and improvement in function and quality of life.
摘要：
复杂区域疼痛综合征是一种慢性衰弱性疼痛障碍，难以治疗，部分原因是其临床表现异质性和缺乏明确定义的病理生理学。患者通常需要多学科的治疗方法，这可能需要药物治疗，物理治疗,行为疗法,和介入疼痛程序，比如交感神经阻滞,脊髓刺激,和背根神经节刺激。然而,许多患者继续经历这些多模式策略难以治疗的疼痛.加扰器疗法（ST）是一种通过皮肤电极应用的神经调节的非侵入性方法，并且可以通过刺激C纤维和用合成的非伤害性信号代替内源性疼痛信号来缓解慢性神经性疼痛。尽管已经报道了使用ST治疗几种类型的难治性中枢和周围神经性疼痛，关于使用ST治疗复杂区域疼痛综合征的数据很少.我们介绍了两名患有右下肢复杂区域疼痛综合征的患者，每个人都接受了ST，并且疼痛得到了显着缓解，功能和生活质量得到了改善。
