Abstract：
Bladder cancer (BLCA) is the most common type of urothelial cancer. The role of metabolic reprogramming in tumors is gradually gaining more attention and being investigated. Recent studies have shown that noncoding RNAs (ncRNAs) are strongly related to BLCA metabolic reprogramming. ncRNAs are able to directly regulate the expression and function of metabolic enzymes, or indirectly regulate them through a number of important pathways to regulate metabolism in BLCA cells. The mechanism of the development of BLCA has not yet, to the best of the authors\' knowledge, been studied and identifying how ncRNAs act in metabolic reprogramming in BLCA may assist with developing BLCA treatments. In the present review, a summary of the ncRNAs participating in the metabolic reprogramming of BLCA was provided. The regulation of ncRNAs in glucose, lipid and amino acid metabolism was also detailed. Furthermore, the molecular mechanisms underlying the regulation of ncRNAs in the metabolic reprogramming of BLCA and potential treatment strategies that track cancer cell metabolism by regulating the expression of particular ncRNAs were discussed.
摘要：
膀胱癌（BLCA）是最常见的尿路上皮癌。代谢重编程在肿瘤中的作用逐渐受到关注和研究。最近的研究表明，非编码RNA（ncRNA）与BLCA代谢重编程密切相关。ncRNAs能够直接调节代谢酶的表达和功能，或通过许多重要途径间接调节它们以调节BLCA细胞的代谢。BLCA的发展机制还没有,据作者所知，已经研究和鉴定ncRNAs在BLCA代谢重编程中的作用可能有助于开发BLCA治疗。在本次审查中，提供了参与BLCA代谢重编程的ncRNAs的总结.葡萄糖中ncRNAs的调节，还详细介绍了脂质和氨基酸代谢。此外，我们讨论了BLCA代谢重编程中ncRNAs调控的分子机制,以及通过调控特定ncRNAs的表达来追踪癌细胞代谢的潜在治疗策略.
