PDF(Pubmed)
Abstract：
UNASSIGNED: Memantine is an N-methyl-d-aspartate (NMDA) receptor antagonist that is used to treat moderate to severe Alzheimer\'s Dementia (AD) and has been speculated to provide clinical benefits in Huntington\'s disease (HD).
UNASSIGNED: To assess the effectiveness of memantine on the trajectory of cognitive decline in individuals with manifest HD.
UNASSIGNED: Using participants from the Enroll-HD study, the primary analysis compared trajectories in cognition over a 5-year period using linear mixed effect models of prevalent and incident memantine users who were propensity-score-matched with non-users on measures of disease progression and demographics.
UNASSIGNED: In the primary analysis there were no significant differences in the trajectories between memantine users and non-users on any primary outcomes of interest.
UNASSIGNED: Memantine use was not associated with any clinical benefit for individuals with manifest HD. Further studies are warranted to assess the impact of memantine on clinical outcomes in HD.
UNASSIGNED: To assess the effectiveness of memantine on the trajectory of cognitive decline in individuals with manifest HD.
UNASSIGNED: Using participants from the Enroll-HD study, the primary analysis compared trajectories in cognition over a 5-year period using linear mixed effect models of prevalent and incident memantine users who were propensity-score-matched with non-users on measures of disease progression and demographics.
UNASSIGNED: In the primary analysis there were no significant differences in the trajectories between memantine users and non-users on any primary outcomes of interest.
UNASSIGNED: Memantine use was not associated with any clinical benefit for individuals with manifest HD. Further studies are warranted to assess the impact of memantine on clinical outcomes in HD.
摘要：
■美金刚是一种N-甲基-d-天冬氨酸（NMDA）受体拮抗剂，用于治疗中度至重度阿尔茨海默氏痴呆症（AD），并被认为可在亨廷顿氏病（HD）中提供临床益处。
■评估美金刚对明显HD患者认知下降轨迹的有效性。
■使用Enroll-HD研究的参与者，主要分析使用流行和事件美金刚使用者的线性混合效应模型,比较了5年期间的认知轨迹,这些患者在疾病进展和人口统计学指标上倾向评分与非使用者匹配.
■在主要分析中，美金刚使用者和非使用者在任何感兴趣的主要结果上的轨迹没有显着差异。
■美金刚的使用与患有明显HD的个体的任何临床益处无关。需要进一步的研究来评估美金刚对HD临床结果的影响。
■评估美金刚对明显HD患者认知下降轨迹的有效性。
■使用Enroll-HD研究的参与者，主要分析使用流行和事件美金刚使用者的线性混合效应模型,比较了5年期间的认知轨迹,这些患者在疾病进展和人口统计学指标上倾向评分与非使用者匹配.
■在主要分析中，美金刚使用者和非使用者在任何感兴趣的主要结果上的轨迹没有显着差异。
■美金刚的使用与患有明显HD的个体的任何临床益处无关。需要进一步的研究来评估美金刚对HD临床结果的影响。
