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Abstract：
FAM83 family members are a group of proteins that have been implicated in various solid tumors. In this updated review, we mainly focus on the cellular localization, molecular composition, and biological function of FAM83 family proteins in solid tumors. We discussed the factors that regulate abnormal protein expression and alterations in the functional activities of solid tumor cells (including non-coding microRNAs and protein modifiers) and potential mechanisms of tumorigenesis (including the MAPK, WNT, and TGF-β signaling pathways). Further, we highlighted the application of FAM83 family proteins in the diagnoses and treatment of different cancers, such as breast, lung, liver, and ovarian cancers from two aspects: molecular marker diagnosis and tumor drug resistance. We described the overexpression of FAM83 genes in various human malignant tumor cells and its relationship with tumor proliferation, migration, invasion, transformation, and drug resistance. Moreover, we explored the prospects and challenges of using tumor treatments based on the FAM83 proteins. Overall, we provide a theoretical basis for harnessing FAM83 family proteins as novel targets in cancer treatment. We believe that this review opens up open new directions for solid tumor treatment in clinical practice.
摘要：
FAM83家族成员是一组与各种实体瘤有关的蛋白质。在此更新的评论中，我们主要关注细胞定位，分子组成，FAM83家族蛋白在实体肿瘤中的生物学功能。我们讨论了调控实体瘤细胞异常蛋白表达和功能活性改变的因素（包括非编码microRNAs和蛋白修饰剂）和肿瘤发生的潜在机制（包括MAPK，WNT,和TGF-β信号通路)。Further,我们强调了FAM83家族蛋白在不同癌症的诊断和治疗中的应用，如乳房，肺，肝脏,从分子标记物诊断和肿瘤耐药两个方面。我们描述了FAM83基因在各种人类恶性肿瘤细胞中的过表达及其与肿瘤增殖的关系。迁移,入侵,改造,和抗药性。此外，我们探讨了基于FAM83蛋白的肿瘤治疗的前景和挑战.总的来说,我们为利用FAM83家族蛋白作为癌症治疗的新靶点提供了理论依据。我们认为，这篇综述为临床实践中的实体瘤治疗开辟了新的方向。
