Abstract：
OBJECTIVE: To compare the efficacy of phakic intra-ocular lenses in isolation or in combination with corneal crosslinking (CXL) and/or intra-stromal corneal ring segments (ICRS) in keratoconus.
METHODS: Data extracted from the publications meeting the selection. The outcome parameters included mean pre- and post-operative uncorrected distance visual acuity, corrected distance visual acuity (CDVA), sphere and cylinder of refraction and complications. Available data analyzed with Cochrane Review Manager.
RESULTS: A total of 23 studies including 464 eyes were included. All the parameters showed significant improvement in all subgroups other than CDVA in ACPIOL + CXL subgroup and cylinder in PIOL + CXL subgroups. There was not a significant difference between PCPIOL and ACPIOL in the outcomes, exception was more improvement of CDVA in \"ACPIOL only\" than\" PCPIOL only\" subgroup.
CONCLUSIONS: Both PCPIOLs and ACPIOLs are comparably safe and efficient options in management of KCN and their efficacy significantly improves when combined with CXL/ICRS.
METHODS: Data extracted from the publications meeting the selection. The outcome parameters included mean pre- and post-operative uncorrected distance visual acuity, corrected distance visual acuity (CDVA), sphere and cylinder of refraction and complications. Available data analyzed with Cochrane Review Manager.
RESULTS: A total of 23 studies including 464 eyes were included. All the parameters showed significant improvement in all subgroups other than CDVA in ACPIOL + CXL subgroup and cylinder in PIOL + CXL subgroups. There was not a significant difference between PCPIOL and ACPIOL in the outcomes, exception was more improvement of CDVA in \"ACPIOL only\" than\" PCPIOL only\" subgroup.
CONCLUSIONS: Both PCPIOLs and ACPIOLs are comparably safe and efficient options in management of KCN and their efficacy significantly improves when combined with CXL/ICRS.
摘要：
目的：比较有晶状体晶状体在圆锥角膜中单独或联合角膜交联（CXL）和/或基质内角膜环段（ICRS）的疗效。
方法：从符合选择的出版物中提取的数据。结果参数包括平均术前和术后未矫正视力，矫正视力（CDVA），球面和柱面的折射和并发症。使用CochraneReviewManager分析可用数据。
结果：共纳入23项研究，包括464只眼。除ACPIOLCXL亚组的CDVA和PIOLCXL亚组的圆柱体外，所有参数均显示出显着改善。PCPIOL和ACPIOL在结果上没有显著差异，例外是“仅ACPIOL”亚组的CDVA比“仅PCPIOL”亚组的CDVA改善更多。
结论：PCPIOL和ACPIOL都是治疗KCN的相对安全和有效的选择，当与CXL/ICRS联合使用时，它们的疗效显着提高。
方法：从符合选择的出版物中提取的数据。结果参数包括平均术前和术后未矫正视力，矫正视力（CDVA），球面和柱面的折射和并发症。使用CochraneReviewManager分析可用数据。
结果：共纳入23项研究，包括464只眼。除ACPIOLCXL亚组的CDVA和PIOLCXL亚组的圆柱体外，所有参数均显示出显着改善。PCPIOL和ACPIOL在结果上没有显著差异，例外是“仅ACPIOL”亚组的CDVA比“仅PCPIOL”亚组的CDVA改善更多。
结论：PCPIOL和ACPIOL都是治疗KCN的相对安全和有效的选择，当与CXL/ICRS联合使用时，它们的疗效显着提高。
