PDF(Pubmed)
Abstract：
A 1-year-old male intact Miniature Schnauzer mix was presented for chronic intermittent hematuria. Abdominal ultrasonography revealed a large, fluid-filled cystic structure extending cranially and dorsally to the prostate. Computed tomography scan images revealed that the fluid-filled cavity resembled a uterus, with both horns entering the scrotum through the inguinal canal adjacent to the testes. On cytogenetic analysis, the dog was found to have a homozygote mutation on AMHRII consistent with persistent Müllerian duct syndrome (PMDS). A gonadohysterectomy was performed, and surgical and histologic findings confirmed the presence of a uterus, oviducts, vagina, and testes in this dog. Additionally, an intraoperative fluoroscopy exam revealed a communication between the uterus and the bladder via an enlarged utricle, explaining the hematuria and urine in the reproductive tract (urometra). To our knowledge, this is the first clinical report of a phenotypically intact male dog with PMDS and urometra due to an enlarged prostatic utricle. This case illustrates a combination of a disorder of sex and urogenital sinus development.
摘要：
针对慢性间歇性血尿，提出了1岁男性完整的小型雪纳瑞混合物。腹部超声检查显示，充满液体的囊性结构向头颅和背侧延伸到前列腺。计算机断层扫描图像显示充满液体的空腔类似于子宫，两个角通过邻近睾丸的腹股沟管进入阴囊。关于细胞遗传学分析，发现该犬在AMHRII上具有纯合子突变，与持续性苗勒管综合征（PMDS）一致。进行了性腺子宫切除术，手术和组织学检查结果证实了子宫的存在，输卵管,阴道,和这只狗的睾丸。此外,术中透视检查显示子宫和膀胱之间通过增大的小脑连通，解释生殖道中的血尿和尿液（尿）。据我们所知,这是因前列腺囊增大而出现PMDS和尿metra的表型完整的雄性犬的首次临床报告。该病例说明了性障碍和泌尿生殖窦发育的组合。
