PDF(Pubmed)
Abstract：
BACKGROUND: Hard metal lung disease (HMLD) is a relatively less known occupational interstitial lung disease, and instances of HMLD resulting from para-occupational exposure are rarely reported.
METHODS: This paper presents two cases of interstitial lung disease caused by exposure to hard metal. The first case involves a 37-year-old Taiwanese man who had worked at a grinder station for hard metal materials for 12 years without respiratory protective equipment. He experienced a dry cough and exertional dyspnea, and his chest imaging and pathology findings were consistent with the features of usual interstitial pneumonia. Analysis of his lung tissue revealed the presence of tungsten and cobalt. The second case involves a 68-year-old Taiwanese woman, the mother of the first patient, who had hand-washed her son\'s workwear. She experienced a dry cough and had similar imaging findings to her son. After her son left his job, they both exhibited improved symptoms and lung functions with nintedanib treatment. These findings suggest a diagnosis of HMLD and interstitial lung disease resulting from para-occupational exposure to hard metal dust.
CONCLUSIONS: The diagnosis of HMLD relies on obtaining a detailed occupational exposure history. If HMLD is diagnosed, discontinuing exposing to hard metal dusts can lead to improved lung function.
METHODS: This paper presents two cases of interstitial lung disease caused by exposure to hard metal. The first case involves a 37-year-old Taiwanese man who had worked at a grinder station for hard metal materials for 12 years without respiratory protective equipment. He experienced a dry cough and exertional dyspnea, and his chest imaging and pathology findings were consistent with the features of usual interstitial pneumonia. Analysis of his lung tissue revealed the presence of tungsten and cobalt. The second case involves a 68-year-old Taiwanese woman, the mother of the first patient, who had hand-washed her son\'s workwear. She experienced a dry cough and had similar imaging findings to her son. After her son left his job, they both exhibited improved symptoms and lung functions with nintedanib treatment. These findings suggest a diagnosis of HMLD and interstitial lung disease resulting from para-occupational exposure to hard metal dust.
CONCLUSIONS: The diagnosis of HMLD relies on obtaining a detailed occupational exposure history. If HMLD is diagnosed, discontinuing exposing to hard metal dusts can lead to improved lung function.
摘要：
背景：硬质金属肺病（HMLD）是一种相对鲜为人知的职业性间质性肺病，很少报告因职业接触而导致的HMLD实例。
方法：本文介绍了2例接触硬质金属引起的间质性肺病。第一例涉及一名37岁的台湾男子，他在硬金属材料的磨床站工作了12年，没有呼吸防护设备。他经历了干咳和劳力性呼吸困难，他的胸部影像学和病理结果与通常的间质性肺炎的特征一致。对他的肺组织的分析显示存在钨和钴。第二起案件涉及一名68岁的台湾女性,第一个病人的母亲,她手洗了儿子的工作服。她经历了干咳，并有与儿子相似的影像学发现。她儿子离职后,尼达尼布治疗后，症状和肺功能均得到改善。这些发现表明，由于职业性接触硬质金属粉尘而导致的HMLD和间质性肺病的诊断。
结论：HMLD的诊断依赖于获得详细的职业暴露史。如果HMLD被诊断出来,停止接触硬金属粉尘可以改善肺功能。
方法：本文介绍了2例接触硬质金属引起的间质性肺病。第一例涉及一名37岁的台湾男子，他在硬金属材料的磨床站工作了12年，没有呼吸防护设备。他经历了干咳和劳力性呼吸困难，他的胸部影像学和病理结果与通常的间质性肺炎的特征一致。对他的肺组织的分析显示存在钨和钴。第二起案件涉及一名68岁的台湾女性,第一个病人的母亲,她手洗了儿子的工作服。她经历了干咳，并有与儿子相似的影像学发现。她儿子离职后,尼达尼布治疗后，症状和肺功能均得到改善。这些发现表明，由于职业性接触硬质金属粉尘而导致的HMLD和间质性肺病的诊断。
结论：HMLD的诊断依赖于获得详细的职业暴露史。如果HMLD被诊断出来,停止接触硬金属粉尘可以改善肺功能。
