PDF(Pubmed)
Abstract：
Prucalopride (PCP) is a medication used for the management of constipation via regulating bowel motions. PCP is widely used all over the world. So, novel, rapid, and highly sensitive carbon dots N-CQDs were obtained from Eruca Sativa juice via microwave approach in 4 min. The luminescence power of N-CQDs was declined by the increasing prucalopride concentration at emission 518 nm with linearity ranged from 3.00 to 200.00 ng mL-1. The luminescent antecedent was utilized for the test of PCP in human plasma with the rate of recovery extending from 95.06 to 98.40%. The new technique is an eco-friendly analytical method that can be easily applied in clinical laboratories. This assay is also simple, sensitive, and applied to therapeutic laboratories and subsequent pharmacokinetic studies in several clinical laboratories. Furthermore, the N-CQDs nano-sensor was able to distinguish the target drug from interferents commonly found in human plasma, indicating its high specificity and selectivity for PCP detection.
摘要：
Prucalopride（PCP）是一种用于通过调节肠道运动来治疗便秘的药物。PCP在世界各地广泛使用。所以,小说,快速,通过微波方法在4分钟内从ErucaSativa果汁中获得了高灵敏度的碳点N-CQD。N-CQDs的发光功率因发射518nm处普鲁卡必利浓度的增加而下降，线性范围为3.00至200.00ngmL-1。发光前因用于人血浆中PCP的测试，回收率从95.06％扩展到98.40％。这项新技术是一种环保的分析方法，可以很容易地应用于临床实验室。这种检测方法也很简单,敏感,并应用于治疗实验室和随后在几个临床实验室的药代动力学研究。此外，N-CQDs纳米传感器能够区分目标药物与人血浆中常见的干扰物，表明其对PCP检测的高特异性和选择性。
