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Abstract：
Background Thyroid cancer is the most common malignant disease in the endocrine glands. Symptoms of the disease affect the functions of organs in the body. Although thyroid cancer is often considered a \"good cancer\" because it progresses slowly, the likelihood of successful treatment is quite high; what is special is that the effect on the quality of life (QoL) is on par with more severe types of cancer. Currently, studies on QoL assessment in thyroid cancer patients are quite limited in southern Vietnam. The present study investigated the potential risk factors of deterioration in QoL scores in thyroid cancer patients after thyroidectomy. Methodology A descriptive, cross-sectional study was performed on a total of 162 patients who were diagnosed with thyroid cancer and underwent thyroidectomy at the University Medical Center Ho Chi Minh City, Vietnam, from February to May 2023. Data were collected through face-to-face interviews with patients and from medical records. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 was used to assess the QoL one month after thyroidectomy. Multivariable logistic regression was used to identify factors related to QoL with statistical significance set at p-value <0.05. Results The mean overall QoL in thyroid cancer survivors was 84.4 ± 10.00 (on a scale of 0-100, where 100 was the best). The results of multivariate logistic regression analysis showed that the factors related to QoL after thyroidectomy were surgery type (p < 0.001), having a comorbidity (p = 0.029), economic status (p = 0.026), and hormone disorder (p = 0.009). Conclusions Our study indicated that surgery type, having a comorbidity, economic status, and hormone disorders were independent risk factors for decreased QoL one month after thyroidectomy. It is necessary to thoroughly assess the QoL before and after surgery in thyroid cancer patients. Longer follow-up QoL studies should be performed with larger sample sizes for more accurate results.
摘要：
背景技术甲状腺癌是内分泌腺中最常见的恶性疾病。该疾病的症状影响身体器官的功能。虽然甲状腺癌通常被认为是“好癌症”，因为它进展缓慢，成功治疗的可能性相当高;特别的是对生活质量(QoL)的影响与更严重类型的癌症相当.目前,在越南南部，甲状腺癌患者QoL评估的研究非常有限。本研究调查了甲状腺切除术后甲状腺癌患者QoL评分恶化的潜在危险因素。方法论描述性的，在胡志明市大学医学中心，对总共162名被诊断为甲状腺癌并接受甲状腺切除术的患者进行了横断面研究，越南,2023年2月至5月。通过与患者的面对面访谈和医疗记录收集数据。欧洲癌症研究和治疗组织生活质量问卷核心30用于评估甲状腺切除术后一个月的QoL。多变量logistic回归用于识别与生活质量相关的因素，统计学意义设置为p值<0.05。结果甲状腺癌幸存者的平均总体QoL为84.4±10.00（在0-100的范围内，其中100是最好的）。多因素logistic回归分析结果显示,与甲状腺切除术后QoL相关的因素为手术类型(p<0.001),具有合并症(p=0.029)，经济状况(p=0.026)，和激素紊乱（p=0.009）。结论我们的研究表明，手术类型，有合并症，经济地位,激素紊乱是甲状腺切除术后1个月QoL下降的独立危险因素。有必要彻底评估甲状腺癌患者手术前后的QoL。应使用更大的样本量进行更长的随访QoL研究，以获得更准确的结果。
