Abstract：
Alzheimer\'s is one of the most common neurodegenerative illnesses that affect brain cellular function. In this disease, the neurons in the brain are considered to be decaying steadily but consistently by the accumulation of amyloid mass, particularly the β-amyloids, amyloid proteins, and Tau proteins. The most responsible amyloid-proteins are amyloid-40 and amyloid-42, which have a high probability of accumulating in excess over the brain cell, interfering with normal brain cell function and triggering brain cell death. The advancement of pharmaceutical sciences leads to the development of Nanotheranostics technology, which may be used to diagnose and treat Alzheimer\'s. They are the colloidal nanoparticles functionalised with the therapeutic moiety as well as a diagnostic moiety. This article discusses the prognosis of Alzheimer\'s, various nanotheranostics approaches (nanoparticles, quantum dots, aptamers, dendrimers, etc), and their recent advancement in managing Alzheimer\'s. Also, various in-vitro and in-vivo diagnostic methodologies were discussed with respect to nanotheranostics.
Describing the pathophysiology of Alzheimer’s with respect to amyloid β in the prognosis of the diseasePresenting the various nanotheranostics techniques for the detection and treatment of Alzheimer’s diseaseNanoparticles, Aptamers, and Dendrimers used as diagnostic and treatment entitiesIn-vivo (MRI, OI) and In-vitro (STM, TRPS) diagnostic approaches for detecting Alzheimer’s disease.
Describing the pathophysiology of Alzheimer’s with respect to amyloid β in the prognosis of the diseasePresenting the various nanotheranostics techniques for the detection and treatment of Alzheimer’s diseaseNanoparticles, Aptamers, and Dendrimers used as diagnostic and treatment entitiesIn-vivo (MRI, OI) and In-vitro (STM, TRPS) diagnostic approaches for detecting Alzheimer’s disease.
摘要：
阿尔茨海默氏症是影响脑细胞功能的最常见的神经退行性疾病之一。在这种疾病中,大脑中的神经元被认为是稳定的衰变，但一致的是淀粉样蛋白的积累，特别是β-淀粉样蛋白，淀粉样蛋白，和Tau蛋白。最负责任的淀粉样蛋白是淀粉样蛋白-40和淀粉样蛋白-42，它们很有可能在脑细胞中积累过多，干扰正常脑细胞功能并引发脑细胞死亡。药物科学的进步导致了Nanotheranosics技术的发展，可用于诊断和治疗阿尔茨海默氏症。它们是用治疗部分以及诊断部分官能化的胶体纳米颗粒。这篇文章讨论了阿尔茨海默氏症的预后，各种纳米热学方法(纳米粒子，量子点,适体,树枝状聚合物,etc),以及他们最近在管理阿尔茨海默氏症方面的进步。此外，讨论了有关nanotheranosics的各种体外和体内诊断方法。
描述阿尔茨海默病关于β淀粉样蛋白在疾病预后中的病理生理学。介绍了用于检测和治疗阿尔茨海默病的各种纳米纳米粒子技术，适体,和树枝状聚合物用作体内诊断和治疗实体(MRI，OI）和体外（STM，TRPS)检测阿尔茨海默病的诊断方法。
描述阿尔茨海默病关于β淀粉样蛋白在疾病预后中的病理生理学。介绍了用于检测和治疗阿尔茨海默病的各种纳米纳米粒子技术，适体,和树枝状聚合物用作体内诊断和治疗实体(MRI，OI）和体外（STM，TRPS)检测阿尔茨海默病的诊断方法。
