PDF(Pubmed)
Abstract：
UNASSIGNED: Vitamin D has been known to be associated with asthma, particularly in children, while the evidence among adults is limited and inconclusive. This study aimed to investigate the association between serum, vitamin D concentrations, and the incidence of adult-onset asthma and also the modified effect caused by sleep patterns and genetic risks.
UNASSIGNED: A prospective cohort study with 307,872 participants aged between 37 and 73 years was conducted based on the UK Biobank, with a median follow-up of 12 years. The Cox proportional hazard model was applied to evaluate the association between vitamin D status and incident adult-onset asthma, and the modified effect was investigated by conducting stratified analysis according to sleep pattern score and genetic risk score, and subgroup analyses were performed by sex, age, BMI, and smoking status as well.
UNASSIGNED: Individuals with optimal vitamin D concentration were associated with 11.1% reduced risk of incident asthma compared to those participants with deficient vitamin D (HR = 0.889; 95% CI: 0.820-0.964; p = 0.005). Moreover, stratification analysis demonstrated that the protective effect of vitamin D on asthma risk was modified by sleep patterns or genetic susceptibility, with the strongest protective effect being observed in the subpopulation with a moderate sleep pattern (HR = 0.883; 95% CI: 0.797-0.977; p = 0.016) and a moderate genetic risk (HR = 0.817; 95% CI: 0.711-0.938; p = 0.004). In subgroup analyses, the protective effect of optimal vitamin D levels was only significant among men, individuals younger than 60 years of age, overweight individuals, and current or previous smokers.
UNASSIGNED: Increased serum vitamin D levels were associated with a lower risk of incident adult-onset asthma, and this association was modified by sleep patterns and genetic predisposition to some extent.
UNASSIGNED: A prospective cohort study with 307,872 participants aged between 37 and 73 years was conducted based on the UK Biobank, with a median follow-up of 12 years. The Cox proportional hazard model was applied to evaluate the association between vitamin D status and incident adult-onset asthma, and the modified effect was investigated by conducting stratified analysis according to sleep pattern score and genetic risk score, and subgroup analyses were performed by sex, age, BMI, and smoking status as well.
UNASSIGNED: Individuals with optimal vitamin D concentration were associated with 11.1% reduced risk of incident asthma compared to those participants with deficient vitamin D (HR = 0.889; 95% CI: 0.820-0.964; p = 0.005). Moreover, stratification analysis demonstrated that the protective effect of vitamin D on asthma risk was modified by sleep patterns or genetic susceptibility, with the strongest protective effect being observed in the subpopulation with a moderate sleep pattern (HR = 0.883; 95% CI: 0.797-0.977; p = 0.016) and a moderate genetic risk (HR = 0.817; 95% CI: 0.711-0.938; p = 0.004). In subgroup analyses, the protective effect of optimal vitamin D levels was only significant among men, individuals younger than 60 years of age, overweight individuals, and current or previous smokers.
UNASSIGNED: Increased serum vitamin D levels were associated with a lower risk of incident adult-onset asthma, and this association was modified by sleep patterns and genetic predisposition to some extent.
摘要：
■已知维生素D与哮喘有关，特别是在儿童中，而成年人的证据有限且尚无定论。本研究旨在探讨血清,维生素D浓度，和成人发作哮喘的发病率，以及睡眠模式和遗传风险引起的改变效应。
■根据英国生物银行，对307,872名年龄在37至73岁之间的参与者进行了一项前瞻性队列研究。中位随访时间为12年。Cox比例风险模型用于评估维生素D状态与成人发作哮喘之间的关系。根据睡眠模式评分和遗传风险评分进行分层分析，亚组分析按性别进行，年龄,BMI,还有吸烟状况。
与维生素D缺乏的参与者相比，具有最佳维生素D浓度的个体发生哮喘的风险降低11.1%(HR=0.889;95%CI:0.820-0.964;p=0.005)。此外，分层分析表明，维生素D对哮喘风险的保护作用是由睡眠模式或遗传易感性改变的。在中度睡眠模式(HR=0.883;95%CI:0.797-0.977;p=0.016)和中度遗传风险(HR=0.817;95%CI:0.711-0.938;p=0.004)的亚群中观察到最强的保护作用。在亚组分析中，最佳维生素D水平的保护作用仅在男性中显著，年龄小于60岁的人，超重个体,和当前或以前的吸烟者。
■血清维生素D水平升高与成年哮喘发病风险降低相关，睡眠模式和遗传易感性在一定程度上改变了这种联系。
■根据英国生物银行，对307,872名年龄在37至73岁之间的参与者进行了一项前瞻性队列研究。中位随访时间为12年。Cox比例风险模型用于评估维生素D状态与成人发作哮喘之间的关系。根据睡眠模式评分和遗传风险评分进行分层分析，亚组分析按性别进行，年龄,BMI,还有吸烟状况。
与维生素D缺乏的参与者相比，具有最佳维生素D浓度的个体发生哮喘的风险降低11.1%(HR=0.889;95%CI:0.820-0.964;p=0.005)。此外，分层分析表明，维生素D对哮喘风险的保护作用是由睡眠模式或遗传易感性改变的。在中度睡眠模式(HR=0.883;95%CI:0.797-0.977;p=0.016)和中度遗传风险(HR=0.817;95%CI:0.711-0.938;p=0.004)的亚群中观察到最强的保护作用。在亚组分析中，最佳维生素D水平的保护作用仅在男性中显著，年龄小于60岁的人，超重个体,和当前或以前的吸烟者。
■血清维生素D水平升高与成年哮喘发病风险降低相关，睡眠模式和遗传易感性在一定程度上改变了这种联系。
