PDF(Pubmed)
Abstract：
UNASSIGNED: The pathomechanisms underlying migraine are intricate and remain largely unclear. Initially regarded as a neuronal disorder, migraine research primarily concentrated on understanding the pathophysiological changes within neurons. However, recent advances have revealed the significant involvement of neuroinflammation and the neuro-glio-vascular interplay in migraine pathogenesis.
UNASSIGNED: A systematic search was conducted in PubMed, Scopus, and Web of Science databases from their inception until November 2022. The retrieved results underwent a screening process based on title and abstract, and the full texts of the remaining papers were thoroughly assessed for eligibility. Only studies that met the predetermined inclusion criteria were included in the review.
UNASSIGNED: Fifty-nine studies, consisting of 6 human studies and 53 animal studies, met the inclusion criteria. Among the 6 human studies, 2 focused on genetic analyses, while the remaining studies employed functional imaging, serum analyses and clinical trials. Regarding the 53 animal studies investigating glial cells in migraine, 19 of them explored the role of satellite glial cells and/or Schwann cells in the trigeminal ganglion and/or trigeminal nerve. Additionally, 17 studies highlighted the significance of microglia and/or astrocytes in the trigeminal nucleus caudalis, particularly in relation to central sensitization during migraine chronification. Furthermore, 17 studies examined the involvement of astrocytes and/or microglia in the cortex.
UNASSIGNED: Glial cells, including astrocytes, microglia, satellite glial cells and Schwann cells in the central and peripheral nervous system, participate both in the development as well as chronic progression of migraine in disease-associated regions such as the trigeminovascular system, trigeminal nucleus caudalis and cortex, among other brain regions.
UNASSIGNED: A systematic search was conducted in PubMed, Scopus, and Web of Science databases from their inception until November 2022. The retrieved results underwent a screening process based on title and abstract, and the full texts of the remaining papers were thoroughly assessed for eligibility. Only studies that met the predetermined inclusion criteria were included in the review.
UNASSIGNED: Fifty-nine studies, consisting of 6 human studies and 53 animal studies, met the inclusion criteria. Among the 6 human studies, 2 focused on genetic analyses, while the remaining studies employed functional imaging, serum analyses and clinical trials. Regarding the 53 animal studies investigating glial cells in migraine, 19 of them explored the role of satellite glial cells and/or Schwann cells in the trigeminal ganglion and/or trigeminal nerve. Additionally, 17 studies highlighted the significance of microglia and/or astrocytes in the trigeminal nucleus caudalis, particularly in relation to central sensitization during migraine chronification. Furthermore, 17 studies examined the involvement of astrocytes and/or microglia in the cortex.
UNASSIGNED: Glial cells, including astrocytes, microglia, satellite glial cells and Schwann cells in the central and peripheral nervous system, participate both in the development as well as chronic progression of migraine in disease-associated regions such as the trigeminovascular system, trigeminal nucleus caudalis and cortex, among other brain regions.
摘要：
■偏头痛的发病机制错综复杂，目前仍不清楚。最初被认为是一种神经元疾病，偏头痛的研究主要集中在了解神经元的病理生理变化。然而,最近的进展表明，神经炎症和神经-神经胶质-血管相互作用在偏头痛发病机制中的重要作用。
■在PubMed中进行了系统搜索，Scopus,和WebofScience数据库从成立到2022年11月。检索到的结果经过了基于标题和摘要的筛选过程，其余论文的全文都经过了彻底的资格评估。只有符合预定纳入标准的研究才被纳入审查。
■59项研究，包括6项人体研究和53项动物研究，符合纳入标准。在6项人体研究中，2专注于遗传分析，而其余研究采用功能成像，血清分析和临床试验。关于研究偏头痛中神经胶质细胞的53项动物研究，其中19个探索了卫星神经胶质细胞和/或雪旺氏细胞在三叉神经节和/或三叉神经中的作用。此外,17项研究强调了三叉神经尾核中小胶质细胞和/或星形胶质细胞的重要性，特别是与偏头痛慢性化过程中的中枢致敏有关。此外，17项研究检查了星形胶质细胞和/或小胶质细胞在皮质中的参与。
■胶质细胞，包括星形胶质细胞,小胶质细胞,中枢神经系统和周围神经系统中的卫星神经胶质细胞和雪旺细胞，参与疾病相关区域如三叉神经血管系统的偏头痛的发展和慢性进展，三叉神经尾核和皮质，在其他大脑区域。
■在PubMed中进行了系统搜索，Scopus,和WebofScience数据库从成立到2022年11月。检索到的结果经过了基于标题和摘要的筛选过程，其余论文的全文都经过了彻底的资格评估。只有符合预定纳入标准的研究才被纳入审查。
■59项研究，包括6项人体研究和53项动物研究，符合纳入标准。在6项人体研究中，2专注于遗传分析，而其余研究采用功能成像，血清分析和临床试验。关于研究偏头痛中神经胶质细胞的53项动物研究，其中19个探索了卫星神经胶质细胞和/或雪旺氏细胞在三叉神经节和/或三叉神经中的作用。此外,17项研究强调了三叉神经尾核中小胶质细胞和/或星形胶质细胞的重要性，特别是与偏头痛慢性化过程中的中枢致敏有关。此外，17项研究检查了星形胶质细胞和/或小胶质细胞在皮质中的参与。
■胶质细胞，包括星形胶质细胞,小胶质细胞,中枢神经系统和周围神经系统中的卫星神经胶质细胞和雪旺细胞，参与疾病相关区域如三叉神经血管系统的偏头痛的发展和慢性进展，三叉神经尾核和皮质，在其他大脑区域。
